Individualizacija prehrane pretile osobe dodatkom prebiotika NUTRIOSE® FB06

master's thesis

• Title (english): Fibre intake as a tool for manipulating gut microbiota in obese individual
• Author: Petra Pešić
• Mentor: Jurica Žučko (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Section for Bioinformatics); Zagreb
• Defense date and country: 2017-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Crijevnoj mikrobioti pridaje je sve veći znaĉaj za dobrobit domaćina te se dovodi u vezu s mnoštvom stanja, od gastrointestinalnih do imunoloških i metaboliĉkih bolesti. Smatra se da ima vaţnu ulogu u nastanku, razvoju i lijeĉenju pretilosti, pri ĉemu mehanizmi djelovanja još nisu razjašnjeni. Prehrana, posebice unos prehrambenih vlakana (prebiotika), jedan je od glavnih ĉimbenika koji pozitivno utjeĉu na mikrobiotu. Ispitali smo koncept moduliranja sastava mikrobiote pomoću prebiotika kod umjereno tjelesno aktivnog pretilog muškarca. Prehrambeni unos i unos vlakana procijenjeni su upitnikom o uĉestalosti konzumacije hrane i pića, 24-satnim prisjećanjem o unosu hrane i pića i dnevnikom prehrane. Intervencija se sastojala od suplementacije komercijalnim prebiotikom NUTRIOSE® FB06, u dozi od 14 g/dan, tijekom 30 dana uz adekvatnu korekciju prehrane, bez restrikcije ukupnog dnevnog energetskog unosa (kcal/dan). Uzorci stolice uzimani su na poĉetku, nakon 15 i 30 dana intervencije kada su provedena i antropometrijska mjerenja. Konaĉan rezultat pokazao je smanjenje tjelesne mase za 4,8%, ukupnog udjela masnoga tkiva za 12,2% te smanjenje stupnja visceralne masnoće za 2 jedinice. Sastav mikrobiote pokazao je desetorostruko povećanje blagotvornog bakterijskog roda Bifidobacterium.

Abstract (english)

Microbiota plays an increasingly important role for the wellbeing of the host. It has been correlated with a plethora of conditions ranging from gastrointestinal to immunological and metabolic diseases. It is believed microbiota plays an important role in the onset, development and treatment of obesity with exact mechanisms still unclear. Diet is one of the major factors affecting microbiota - especially intake of dietary fibers (prebiotics) which are believed to positively affect microbiota composition. We had tested the concept of modulating microbiota composition using prebiotics in a moderately physically active obese male. Dietary intake and fiber intake were assessed at the beginning using a food frequency questionnaire (FFQ, 24-hour dietary recall and 3-day food record. Intervention consisted of daily supplementation with commercial prebiotic NUTRIOSE® FB06 till recommended daily intake of fiber was achieved. No major change of dietary style and calorie intake was recommended. Intervention was carried out for 30 days and body height, weight and composition were measured and stool samples were taken at the beginning, after 15 days and after 30 days of intervention. Anthropometric parameters showed 4.8% decrease in body weight with a significant reduction of body fat (12.2%) and a decrease in visceral fat rating from 15 to 13. Microbiota composition showed a significant increase in the beneficial bacterial genus Bifidobacterium which increased tenfold during intervention.

• Keywords: mikrobiota; pretilost; prebiotici; dodaci prehrani
• Keywords (english): microbiota; obesity; prebiotics; dietary supplements
• Language: croatian
• URN:NBN: urn:nbn:hr:159:196443
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-09 09:23:03