Konjugati ferocenskih peptida s pikolinskom kiselinom

master's thesis

• Title (english): Conjugates of ferrocene peptide with picolinic acid
• Author: Ivana Martić
• Mentor: Lidija Barišić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2015-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Među metalocenima, najranije terapeutski korištenim organometalnim spojevima, posebno mjesto zauzima ferocen. U konjugatima s prirodnim aminokiselinama i peptidima ima ulogu začetnika okreta i plohi uslijed tvorbe intramolekulskih vodikovih veza. 1,1’-disupstituirani ferocenski peptidi dijele se u tri glavne skupine, od kojih je nama najzanimljivija ona izvedena iz ferocen-1,1ʼ-diamina (Fcda). Pošto je pikolinska kiselina (PA) važan biološki ligand i primarni prirodni kelator esencijalnih elemenata u tragovima, nameće se ideja za sintezom dodataka prehrani i lijekova koji sadrže PA. Uloga metalnih iona je krucijalna, jer su prisutni u svim staničnim strukturama i sudjeluju u mnogim staničnim procesima. U ovom diplomskom radu provedena je sinteza peptida PA-D-Ala-L-Pro-NH-Fn-NH-L-Pro-PA i njegova preliminarna konformacijska analiza korištenjem spektroskopskih metoda.

Abstract (english)

Among the metallocenes, the earliest therapeutically used organometallic compounds, ferrocene takes the special position. In its conjugates with natural amino acids and peptides, ferrocene induces the formation of the turns and sheets, owing to the presence of the intramolecular hydrogen bonds. 1,1'-disubstituted ferrocene peptides are divided in three main groups. We are essspecially interested in peptides derived from ferrocene-1,1'-diamine (Fcda). Since the picolinic (PA) acid is the important biological ligand and primary natural chelator of essential elements in traces, this imposes the idea for the synthesis of medicines and food supplements containing the PA. The role of metal ions is crucial, due to their presence in all cellular structures and involvement in many cellular processes. Within this work, we have been conducted the synthesis of peptide PA-D-Ala-L-Pro-NH-NH-Fn-L-Pro-PA and its preliminar conformational analysis by using spectroscopic methods.

• Keywords: Ferocen; ferocenski konjugati; metalni ioni; pikolinska kiselina; kelatori
• Keywords (english): Ferrocene; ferrocene conjugates; metal ions; picolinic acid; chelators
• Language: croatian
• URN:NBN: urn:nbn:hr:159:710932
• Study programme: Title: Molecular Biotechnology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-04 09:34:13