Biodostupnost i zaštitni učinci polifenola

undergraduate thesis

• Title (english): Bioavailability and protective effects of polyphenols
• Author: Antonija Kadoić
• Mentor: Irena Landeka Jurčević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Food Chemistry and Biochemistry); Zagreb
• Defense date and country: 2015-09-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Interdisciplinary Technical Sciences

Abstract

Polifenoli su sveprisutne molekule u prirodi i široko rasprostranjene u hrani biljnog porijekla. Značajno su prisutni i u ljudskoj prehrani. Polifenoli pokazuju raznolike biološke učinke in vitro i in vivo, kojima potpomažu ljudsko zdravlje.Jedno od njihovih djelovanja je da štite stanice od oksidacijskih oštećenja uzrokovanih slobodnim radikalima i drugim oksidansima. Osim antioksidacijskog djelovanja, polifenoli imaju i druga djelovanja kao što su antiartritično, antitrombotsko, antiviralno, antibakterijsko djelovanje, itd. Svojim iznimnim svojstvima štite organizam čovjeka od nastanka i razvoja kardiovaskularnih bolesti, raka, neurodegenerativnih bolesti i mnogih drugih kroničnih bolesti. Kako bi polifenoli mogli djelovati, moraju biti biodostupni organizmu. Biodostupnost raznih polifenolnih spojeva se razlikuje od jednog polifenola do drugog i ovisi o njihovoj strukturi i metaboličkim reakcijama koje prolaze polifenoli. Potrebna su daljnja istraživanja kako bi se ustanovilo kako se mijenja biodostupnost svakog polifenola i mehanizme kojima djeluju u cilju potvrđivanja njihovih zaštitnih učinaka na ljudsko zdravlje.

Abstract (english)

Polyphenols are ubiquitous molecules in the nature, and widely spread in food of plant origin. They are considerable part of the human diet. Polyphenols exhibit a variety of biological effects in vitro and in vivo, which promote human health. One of their actions is to protect cells against oxidative damage caused by free radicals and other oxidants. In addition to the antioxidative action, the polyphenols have other activity, such as an antiarthritic, antithrombotic, anti-viral and antibacterial action. Its exceptional properties protect the human body from the occurrence and development of cardiovascular diseases, cancer, neurodegenerative diseases, and many other chronic diseases. In order to have protective effects, they have to be bioavailable to the organisms. The bioavailability of various polyphenol compounds are different from one another and depend on their structure and metabolic reactions. Further research is needed to determine how bioavailability of every polyphenol changes and mechanisms by which they work in order to confirm their protective effects on human health.

• Keywords: biodostupnost; metabolizam polifenola; sulfatacija i glukuronidacija
• Keywords (english): bioavailability; metabolismofpolyphenols; sulfationandglucuronidation
• Language: croatian
• URN:NBN: urn:nbn:hr:159:724255
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-12-14 13:45:42