Uloga proteina aksina i beta-katenina u Wnt signalnom putu zdravih stanica i stanica meningeoma

undergraduate thesis

• Title (english): The role of Axin and beta-catenin in Wnt signaling pathway in healthy and meningioma cells
• Author: Ana Grubišić
• Mentor: Reno Hrašćan (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2017-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

U ovom radu su prikazane uloge proteina aksina i β-katenina kao ključnih komponenti Wnt signalnog puta u zdravim stanicama i u meningeomima. Osim što ima ulogu kao glavna signalna molekula Wnt puta, β-katenin je također dio međustaničnih spojeva zajedno s E-kaderinom. Do nastanaka i progresije meningeoma dolazi zbog narušavanja međustaničnih spojeva, tako da će smanjen broj molekula stanične adhezije dovesti do povećane proliferacije tumorskih stanica i može doprinijeti invazivnoj sposobnosti meningeoma. Aksin djeluje kao tumor supresor u karcinomu, ali njegova uloga u meningeomima još nije dovoljno razjašnjena. Ipak, gubitak heterozigotnosti AXIN1 gena u meningeomima može upućivati na njegovu ulogu kao tumor supresora te na posljedično smanjenje razine proteina aksina.

Abstract (english)

This paper studies the roles of β-catenin and Axin as key components of Wnt signaling pathway in healthy and meningioma cells. In addition to having a role as a key signaling molecule of Wnt signaling pathway, β-catenin is also a part of the adherens junctions together with E-cadherin. The occurence and progression of meningiomas are due to disrupted adherens junctions and the decrease in cell adhesion molecules may lead to increased tumor cell proliferation and it may contribute to invasive ability of meningioma. Axin acts as a tumor suppressor in cancer, but its role in meningiomas remains unresolved. However, the loss of heterozygosity of AXIN1 gene in meningiomas may indicate its role as a tumor suppressor and suggest consequent down-regulation of its protein.

• Keywords: aksin; β-katenin; meningeom; Wnt signalni put
• Keywords (english): Axin; β-catenin; meningioma; Wnt signaling pathway
• Language: croatian
• URN:NBN: urn:nbn:hr:159:737236
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-20 08:02:49