Fiziološka uloga n-acetilcisteina

undergraduate thesis

• Title (english): Physiological role of n-acetylcysteine
• Author: Lana Nikolić
• Mentor: Domagoj Đikić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Nutrition Science); Zagreb
• Defense date and country: 2011-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Slobodni radikali su nestabilne kemijske čestice koje u vanjskoj ljusci imaju jedan ili više nesparenih elektrona. Slobodni radikali mogu uzrokovati lipidnu peroksidaciju i oksidacijski stres. Antioksidansi su tvari koje u malim koncentracijama, u odnosu prema oksidabilim supstratima, dovode do odgađanja ili inhibicje oksidacije supstrata. Prema načinu antioksidacijske zaštite antioksidansi mogu biti enzimski i neenzimski. Glutation je jedna od najvažnijih molekula u neenzimskoj antioksidativnoj zaštiti. Smanjena koncentracija glutationa se povezuje sa procesom starenja, patogenezom različitih bolesti jetre, pluća, neurodegenerativnih i autoimunih bolesti. N-acetilcistein ima najveću biodostupnost od svih prekursora glutationa i može nadopuniti njegove unutarstanične zalihe. Djeluja kao antioksidans, antimutagen i antikancerogen. Oralna primjena N-acetilcisteina nema klinički značajnih štetnih učinaka, te se njegova primjena pokazala korisnom u stanjima u kojima se javlja manjak glutationa kao što su HIV infekcija, dijabetes i cistična fibroza, pri trovanju paracetamolom i teškim metalima.

Abstract (english)

Free radicals are very unstable molecules or molecular fragments which containe one or more unpaired electrons. They can cause oxidative stress or lipid peroxidation. Antioxidants are substances capable of preventing or slowing the oxidation of other molecules. By the type of their protection antioxidants can be enzymatic and nonenzymatic. Glutathione is the most important small molecule in antioxidant protection. Glutathione deficiency is linked to aging process and pathogenesis of different liver, pulmonary, neurodegenerative and autoimmune diseases. N-acetylcysteine is the most bioavaliable precursor of glutathione which can replenish depleted intracellular glutathione levels. NAC has antioxidant, antimutagenic and anticarcinogenic functions. Oral administration of NAC has no clinically significant adverse effects and has been shown to be beneficial in settings where glutathione deficiency occurs, for example, HIV infection, cystic fibrosis and diabetes, and in the management of paracetamol overdose or heavy metal poisoning.

• Keywords: N-acetilcistein; glutation; oksidacijski stres
• Keywords (english): N-acetylcysteine; Glutathione; oxidative stress
• Language: croatian
• URN:NBN: urn:nbn:hr:159:483148
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-18 09:41:55