Enzimska dijagnostika infarkta miokarda

master's thesis

• Title (english): Enzymatic diagnosis of myocardial infarction
• Author: Goran Hajdinjak
• Mentor: Jagoda Šušković (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology); Zagreb
• Defense date and country: 2011-12-05, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

U industrijski razvijenim zemljama od kardiovaskularnih bolesti oboljeva oko 15 milijuna ljudi, a oko 20% svih smrti uzrokovano je srčanim bolestima. Zbog toga ima veliki značaj rana i kasna dijagnostika infarkta miokarda. Akutni infarkt miokarda (AIM) je ishemična bolest srca, a nastaje zbog nedovoljne opskrbe srca krvlju, odnosno nutrientima i kisikom. Vrlo često dolazi do opstrukcije ili čak i potpunog prekida dotoka krvi jedne ili više koronarnih arterija zbog stvaranja ateromatoznih plakova za čije su nastajanje značajni čimbenici: starosna dob, spol (muški), genetske predispozicije, hiperlipidemija, pušenje, abnormalni tlak, šećerna bolest, stres, fizička neaktivnost i pretilost. Za dijagnozu AIM trebaju se pratiti povijest bolesti, EKG te srčani biljezi u krvnom serumu. U medicinsko-biokemijskoj dijagnostici važni su srčani markeri te je njihova primjena doživjela transformaciju počevši od upotrebe aspartat aminotransferaze i laktat dehidrogenaze, pa sve do korištenja mioglobina, kreatin kinaze i izoenzima MB kreatin kinaze te troponinskog kompleksa – troponin I i T, koji se primjenjuju u novije vrijeme u hitnoj medicini za procjenu tegoba i boli u grudima. Cilj ovog rada je prikazati enzimsku dijagnostiku na uzorku od dvadeset pacijenata internog odjela koji su obrađeni i praćeni u medicinsko-biokemijskom laboratoriju ŽBČ (Županijske bolnice Čakovec), a imaju dijagnozu akutnog infarkta miokarda.

Abstract (english)

In industrialized countries, cardiovascular diseases get about 15 million people and about 20% of all deaths are caused by heart disease. Therefore early and late diagnosis of myocardial infarction is of great importance. Acute myocardial infarction is an ischemic heart disease which occurs due to insufficient supply of the heart with blood, nutrients and oxygen. Very often there is an obstruction or even a complete interruption of the blood of coronary arteries due to the formation of atheroma plaques in whose creation are important factors: age, gender (male), genetic predisposition, hyperlipidemia, smoking, abnormal blood pressure, diabetes, stress, physical inactivity and obesity. For the diagnosis of myocardial infarction should be monitored medical history, ECG and cardiac markers in blood serum. Biochemical cardiac markers are important in medical diagnostics and their application has experienced an transformation starting with usage of aspartate aminotransferase and lactate dehydrogenase to myoglobin and creatine kinase to troponin complex – troponin I and T, which is used in emergency medicine for assessment of symptoms and chest pain. The aim of this paper is to present a diagnostic enzyme picture in a sample of twenty patients from coronary care unit which are processed and tracked in medical-biochemical laboratory of Čakovec County Hospital, and received a diagnosis of myocardial infarction.

• Keywords: akutni infarkt miokarda; biokemijski biljezi; srčani troponini; kreatin kinaza
• Keywords (english): acute myocardial infarction; diagnostic markers; cardiac troponins; creatine kinase
• Language: croatian
• URN:NBN: urn:nbn:hr:159:713407
• Study programme: Title: Biotechnology; specializations in: Biochemical Engineering; Course: Biochemical Engineering; Study programme type: university; Study level: graduate; Academic / professional title: diplomirani inženjer biotehnologije; smjer biokemijsko inženjerstvo (diplomirani inženjer biotehnologije; smjer biokemijsko inženjerstvo)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-31 08:00:31