Phytoestrogens - biological effects and health risks

undergraduate thesis

• Title: Fitoestrogeni-biološki učinci i zdravstveni rizici
• Author: Ana Mikić
• Mentor: Ivana Kmetič (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Toxicology); Zagreb
• Defense date and country: 2016-09-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Fitoestrogeni su tvari biljnog porijekla koji strukturno odgovaraju estrogenu u sisavaca te im to svojstvo omogućava da se vežu na ljudske estrogen receptore. Pokazuju estrogene i antiestrogene učinke. Fitoestrogeni se dijele na četiri grupe fenolnih spojeva: izoflavone, kumestane, lignane i stilbene. Mogu se pronaći u mahunarkama, cjelovitim žitaricama, sjemenkama te voću i povrću. Biološki učinci koje fitoestrogeni ispoljavaju u ljudskom organizmu znanstvenicima su vrlo zanimljivi jer su brojne bolesti hormonski ovisne. Fitoestrogeni pokazuju povoljne učinke pri liječenju raka dojke, kardiovaskularnih bolesti, raka prostate, osteoporoze, na smanjenje menopauzalnih simptoma te poboljšanje kognitivnih sposobnosti, ali i štetne učinke poput oštećenja muškog i ženskog reproduktivnog sustava. Međutim, brojne studije su pokazale proturječne rezultate te se ne može donijeti konačan zaključak o utjecaju fitoestrogena na ljudsko zdravlje u smislu prevencije i liječenja bolesti.

Abstract (english)

Phytoestrogens are substances of plant origin that structurally correspond to estrogen in mammals. This property allows them to bind to the human estrogen receptor. Phytoestrogens show estrogenic and anti-estrogenic effects. Phytoestrogens are divided into four groups of phenolic compounds: isoflavones, coumestans, lignans and stilbenes. They can be found in legumes, whole grains, seeds, fruits and vegetables. Scientists find that biological effects that phytoestrogens manifest in the human organism are very interesting because many diseases are hormone dependent. Phytoestrogens show beneficial effects in the treatment of breast cancer, cardiovascular disease, prostate cancer, osteoporosis, reducing menopausal symptoms and improving cognitive abilities but also adverse effects such as damage to the male and female reproductive system. However, numerous studies have shown conflicting results, therefore no final conclusion on the effect of phytoestrogens on human health in terms of prevention and treatment of disease can be made.

• Keywords: biološki učinci; estrogen receptor; fitoestrogeni; zdravstveni rizici
• Keywords (english): biological effects; estrogen receptor; health risks; phytoestrogens
• Language: croatian
• URN:NBN: urn:nbn:hr:159:220522
• Study programme: Title: Nutricionizam; Study programme type: sveučilišni; Study level: preddiplomski; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-04-24 11:54:04