Uloga E-kaderina i APC-a u Wnt signalnom putu zdravih stanica i stanica meningeoma

undergraduate thesis

• Title (english): Role of E-cadherin and APC in Wnt signaling pathway of healthy and meningioma cells
• Author: Valentina Fižulić
• Mentor: Reno Hrašćan (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2017-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Signalni putevi tvore kompleksnu molekularnu mreţu unutar stanice, a njihovo normalno funkcioniranje odrţava staničnu homeostazu. Wnt signalni put je kroz evoluciju sačuvan put koji regulira presudne aspekte tijekom embriogeneze, a poremećaji u njegovom radu mogu dovesti do nastanka tumora. U ovom radu su objedinjena dosadašnja saznanja o ulogama dvaju proteina, E-kaderina i APC-a, u normalnom funkcioniranju Wnt signalnog puta te zabiljeţenim promjenama ovih proteina koje dovode do nastanka ili progresije meningeoma – tumora koji su najčešće spororastući i benigni, koji pripadaju skupini tumora središnjeg ţivčanog sustava te nastaju iz arahnoidalnih stanica.

Abstract (english)

Signaling pathways form a complex molecular network within the cell, and their normal functioning maintains cell homeostasis. Wnt signaling pathway is evolutionary conserved pathway that regulates crucial aspects during embryogenesis, and disorders in its work can lead to development of tumors. In this paper, the present knowledge of the role of two proteins, E-cadhrein and APC, in the normal functioning of Wnt signaling pathway and the observed changes in these proteins leading to the development or progression of meningiomas has been unified. Meningeomas are usually slow-growing benign tumors classified as central nervous system tumors and are formed from arahanoidal cells.

• Keywords: APC; E-kaderin; meningeomi; Wnt signalni put
• Keywords (english): APC; E-cadherin; meningiomas; Wnt signaling pathway
• Language: croatian
• URN:NBN: urn:nbn:hr:159:863894
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-19 12:32:49