Odnos mineralne gustoće kosti, homocisteina i vitaminskog statusa s obzirom na dob, prehranu i način života

doctoral thesis

• Title (english): Relationship between bone mineral density, homocysteine and vitamin status according to age, nutrition and lifestyle
• Author: Romana Kajfež
• Mentor: Irena Colić-Barić (mentor)
• Committee member: Ines Panjkota-Krbavčić (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2012-07-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

Povišena konzumacija cirkulirajućeg homocisteina (Hcy) mogući je čimbenik rizika od osteoporoze. Cilj rada bio je utvrditi odnos Hcy, folata, vitamina B12 i mineralne gustoće kosti (BMD) s obzirom na dob, prehranu i način života. Obrnuto proprocionalni prediktori koncentracije Hcy su koncentracije folata u serumu (S), eritrocitima (E) i vitamina B12 u cijelom uzorku, folata (E) i vitamina B12 u omnivora, folata (E) u vegetarijanaca i vitamina B12 u postmenopauzalnih žena omnivora. U cijelom uzorku najznačjniji prediktor BMD na svim mjerenim mjestima je unos ugljikohidrata, (%kJ/dan), za BMD vrata femura i cijelog kuka su i unos tjestenine, riže, kruha i krumpira (g/dan) i natrija. Koncentracija Hcy prediktor je BMD cijelog kuka U omnivora najznačjniji prediktor BMD lumbalne kralježnice je unos vitamin B12, BMD vrata femura unos vlakana, trigliceriga i koncentracija fosfora, BMD cijelog kuka unos ugljikohidrata, vitamina A i triglicerida. U vegetarijanaca najznačjniji prediktor BMD na svim mjerenim mjestima je unos vitamina A, za BMD vrata femura i femur su i unos triglicerida. Unos ugljikohidrata prediktor je samo BMD cijelog kuka. U postmenopauzalnih žena omnivora najznačjniji prediktor BMD na svim mjerenim mjestima je unos ugljikohidrata, (%kJ/dan), za BMD vrata femura i cijelog kuka su i unos vitamina K. Unos cinka prediktor je BMD cijelog kuka. Navedeni odnosi niske su biološke jakosti u odnosu na dob, spol i menopauzalni status. Unutar skupina utvrđena je razlika u BMD na svim mjerenim mjestima. BMD lumbalne kraljžnice i vrata femura imao je najviše vrijednosti u vegetarijanca. Prehrana među skupinama se razlikovala.

Abstract (english)

The objective of this study was to determine the relation between homocysteine (Hcy), folate, vitamin B12 and bone mineral density (BMD) in correlation with age, nutrition and lifestyle. Inversely proportional predictors of Hcy level are levels of serum folate (S), erythrocyte folate (E) and vitamin B12 for the entire sample, folate (E) and vitamin B12 in omnivores, folate (E) in vegetarians and vitamin B12 in omnivorous postmenopausal women. Most significant BMD predictor for the entire sample and for all measurement points is carbohydrate intake (% kJ/day), BMD predictor for femoral neck and total hip is pasta, rise, bread and potato intake (g/day) as well as sodium intake. Hcy level is a BMD predictor for the total hip. In omnivores, most significant BMD predictor for lumbar spine is vitamin B12 intake, for femoral neck BMD fiber and triglyceride intake and level of phosphorous, for total hip BMD carbohydrate intake as well as vitamin A and triglycerides. Most significant BMD predictor for vegetarians in all measurement points is vitamin A intake, for femoral neck BMD and femur BMD is also triglyceride intake. Carbohydrate intake is only the predictor for total hip BMD. In omnivorous postmenopausal women the most significant BMD predictor in all measurement points is carbohydrate intake, (% kJ/day), BMD predictor for femoral neck and total hip is also vitamin K intake. Intake of zinc is the BMD predictor for the total hip. Mentioned relations indicate low biological value in correlation with age, gender and menopausal status. Distinction between BMD has been determined in all measurement points within all groups. Lumbar spine BMD and femoral neck BMD showed the highest values. Nutrition differed between the groups.

• Keywords: mineralna gustoća kosti; homocistein; folat; vitamin B12; spol; dob; prehrana; način života
• Keywords (english): Bone mineral density; homocysteine; folate; vitamin B12; age; gender; nutrition; lifestyle
• Language: croatian
• URN:NBN: urn:nbn:hr:159:135085
• Promotion: 2013-06-30
• Study programme: Title: Postgraduate PhD Study in Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam (doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-16 11:26:06