Priprema i karakterizacija kopulata ferocenoil klorida i citozina

undergraduate thesis

• Title (english): Synthesis and characterization of cytosine's ferrocene compounds
• Author: Jelena Ostojić
• Mentor: Senka Djaković (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2015-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology

Abstract

Organometalni spojevi koji sadrže atom željeza, feroceni, poznati su po svom širokom spektru biološkog djelovanja. Reagirajući s biomolekulama, posebice s DNA, nastaju kopulati koji su pokazali antitumorsko djelovanje in vivo, te antibakterijsko i antiviralno djelovanje. U okviru ovog završnog rada pripravljen je kopulat koji nastaje povezivanjem ferocenoila i nukleobaze citozina preko amino skupine (NH2) vezane na C4-atom citozina. Njegova je struktura potvrĎena primjenom IR, 1H i 13C NMR spektroskopije. U daljnjem tijeku istraživanja potrebno je zaštiti amino skupinu citozina prije deprotekcije ili promijeniti reakcijske uvjete kako bi došlo do usmjeravanja reakcije u N1-položaj.

Abstract (english)

Iron-containing organometallic compounds, ferrocenes, are known to exhibit a wide range of biological activities. Interactions between ferrocenes and biomolecular targets, especially DNA, result with conjugates which have shown antitumor capability when studied in vivo and also antibacterial and antiviral activities. In this final work, conjugate was prepared by reaction of ferocenoil and nucleobase cytosine on the amino group (NH2) linked to C4-atom of the base. The structure of conjugate was confirmed by IR, 1H- and 13C-NMR spectroscopy. In further research, it is necessary to protect amino group before deprotection or to change reaction conditions in order to direct the reaction into N1-position.

• Keywords: biokonjugati; ferocen; citozin; sinteza; spektralna analiza
• Keywords (english): bioconjugates; ferrocene; cytosine; synthesis; spectral analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:808790
• Study programme: Title: Food Technology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-04-26 09:33:17