Protektivni učinci polifenola pri izloženosti organoklornim spojevima

undergraduate thesis

• Title (english): Protective effects of polyphenols against exposure to organochlorine compounds
• Author: Anica Jurišić
• Mentor: Ivana Kmetič (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Toxicology); Zagreb
• Defense date and country: 2019-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Organoklorni spojevi su toksični spojevi koji nastaju tijekom različitih industrijskih procesa, procesa izgaranja i postupaka spaljivanja otpada te se koriste u poljoprivredi kao agrokemikalije. Izloženost organoklornim spojevima predstavlja veliku opasnost za ljudsko zdravlje. Učestalom ekspozicijom organoklornim spojevima narušava se normalno funkcioniranje organizma i dolazi do indukcije oksidacijskog stresa i upalnih procesa koji mogu voditi do pojave raznih kroničnih i malignih bolesti. Polifenoli su spojevi široko zastupljeni u prirodi, a nastaju kao sekundarni metaboliti u biljkama kao posljedica štetnog UV zračenja te štetnog djelovanja radikala. Polifenoli su spojevi koji imaju visoko antioksidacijsko i protuupalno djelovanje stoga se smatra kako mogu djelovati povoljno pri izloženosti tvarima koje izazivaju oksidacijski stres i upalne procese u ljudskom organizmu. U ovom radu objedinjeni su dokazi o protektivnim učincima polifenola pri toksičnosti izazvanoj organoklornim spojevima, kao i objašnjeni predloženi mehanizmi njihovog protektivnog djelovanja.

Abstract (english)

Organochlorine compounds are toxic chemicals that are produced in different industrial processes, combustion processes, waste incineration and are used in agriculture as pesticides. Exposure to organochlorine compounds represents a great risk for human health. Common exposure to organochlorine compounds can impair normal function of organism and cause oxidative stress and inflammation which can lead to many chronic and malignant diseases. Polyphenols are compounds which are widely distributed in fruits, vegetables, seeds and nuts. They are formed as secondary metabolites in plants as a result of harmful UV radiation and damaging actions of free radicals. Polyphenols have high antioxidant and anti-inflammatory activity, therefore they are considered to be beneficial for exposure to substances that cause oxidative stress and inflammatory processes in the human body. This paper consolidates protective effects of polyphenols on organochlorine compounds-induced toxicity, and explains the proposed mechanisms for their protective action.

• Keywords: antioksidansi; organoklorni spojevi; polifenoli; protektivno djelovanje; toksičnost
• Keywords (english): antioxidants; organochlorine compounds; polyphenols; protective effects; toxicity
• Language: croatian
• URN:NBN: urn:nbn:hr:159:759253
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2019-09-23 09:35:11