Izloženost polikloriranim bifenilima na području Republike Hrvatske i toksični učinci na reprodukcijski sustav čovjeka

undergraduate thesis

• Title (english): Polychlorinated biphenyls exposure in Republic of Croatia and toxic effects on human reproductive system
• Author: Marko Čvrljak
• Mentor: Teuta Murati (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Toxicology); Zagreb
• Defense date and country: 2019-09-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Poliklorirani bifenili (PCB) su sintetski organoklorirani spojevi koji pripadaju skupini spojeva poznatoj kao perzistentni organski zagađivači. Usprkos zbranjenoj proizvodnji i upotrebi, zbog visoke otpornosti i sposobnosti bioakumulacije i biomagnifikacije, PCB su i dalje široko rasprostranjeni u okolišu. U ovom preglednom radu, prikazani su rezultati studija provedenih na području Republike Hrvatske, koje su proučavale razine PCB-a u zraku, tlu, vodama, životinjama i majčinom mlijeku. Koncentracije PCB-a u gotovo svim analiziranim uzorcima imaju uobičajeno niske vrijednosti u skladu s vrijednostima dobivenim u drugim zemljama, izuzev uzoraka prikupljenih u procjednim vodama na Zadarskom području u blizini oštećene trafostanice, što se prepisuje posljedicama ratnih razaranja za vrijeme Domovinskog rata. Nadalje, prikazani su mogući toksični učinci PCB-a na reprodukcijski sustav čovjeka poput nepravilnosti u menstrualnom ciklusu, smanjene plodnosti i smanjenog fetalnog rasta te endometrioze kod žena, dok su kod muškaraca zabilježeni smanjena pokretljivost spermija, smanjena razina serumskog testosterona te inhibicija razvoja sekundarnih spolnih karakteristika.

Abstract (english)

Polychlorinated biphenyls (PCBs) are synthetic organochlorinated compounds that belong to a group of compounds known as Persistent Organic Pollutants. Despite the banned use and production, due to the high resistance and capability of bioaccumulation and biomagnification, PCBs are still widespread in the environment. This review presents the results of studies conducted in the Republic of Croatia that examined PCB levels in air, soil, water, animals and breast milk. PCB concentrations in almost all analyzed samples have generally low values in accordance with values obtained in other countries, except for samples collected in leachate in the Zadar area near the damaged transformer station, which was a result of military activities during the Patriotic War. Furthermore, possible toxic effects of PCBs such as menstrual irregularities, impaired fertility, decreased fetal growth and endometriosis were shown in a woman, while decreased sperm motility and serum testosterone levels along with inhibiton of secondary sexual characteristics have been recorded in men.

• Keywords: izloženost; poliklorirani bifenili; reprodukcijski sustav; Republika Hrvatska; toksičnost
• Keywords (english): exposure; polychlorinated biphenyls; reproductive system; Republic of Croatia; toxicity
• Language: croatian
• URN:NBN: urn:nbn:hr:159:776957
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-09-24 07:10:02