Usporedba nutritivnog statusa i kakvoće prehrane oboljelih od celijakije i bolesnika s osjetljivošću na gluten nevezanom za celijakiju (NCGS)

master's thesis

• Title (english): Comparison of nutritional status and quality of diet of patients suffering from celiac disease and patients suffering from non-celiac gluten sensitivity (NCGS)
• Author: Valentina Vučinić
• Mentor: Darija Vranešić Bender (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Nutrition Science); Zagreb
• Defense date and country: 2018-09-21, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Celijakija je bolest probavnog sustava pri kojoj dolazi do oštećenja tankog crijeva uslijed
autoimune reakcije na gluten. Osjetljivost na gluten nevezana za celijakiju skraćeno nazvana NCGS je
poremećaj čija se dijagnoza postavlja u slučaju kada su celijakija i alergija na pšenicu eliminirani kao
mogući uzročnici gastrointestinalnih simptoma. Cilj ovoga rada je bio procijeniti prehrambene navike,
nutritivni status i kvalitetu života pacijenata Kliničkog bolničkog centra Zagreb – Rebro koji boluju od
celijakije i NCGS – a, a čija je dijagnoza postavljena u odrasloj dobi. Provedena su antropometrijska,
dijetetička i laboratorijska ispitivanja. Dnevnike prehrane ispunilo je ukupno 28 pacijenata, 21 pacijent
sa celijakijom i 7 pacijenata s NCGS-om. U prosjeku pacijenti imaju adekvatnu tjelesnu masu i nizak
nutritivni rizik, međutim oboljeli od celijakije imaju prosječno veće vrijednosti indeksa tjelesne mase
(ITM), a prema CD-QOL (Celiac Disease Quality of Life) obrascu bolje ocjenjuje kvalitetu života od
NCGS skupine. Prema laboratorijskim parametrima gotovo svi novodijagnosticirani pacijenti s
celijakijom imaju lezije tipa Marsh 3 (atrofija crijevnih resica), a ispitanicima koji se pridržavaju stroge
bezglutenske prehrane stanje se kroz godinu dana u pravilu normalizira, ispitanici s NCGS-om nemaju
oštećenje sluznice crijeva. Također, kod skupine s celijakijom tTg vrijednosti sukladno pridržavanju
bezglutenske prehrane snižavaju se do poželjnih vrijednosti.

Abstract (english)

Celiac disease is a digestive system disorder that causes small bowel damage due to autoimmune response to gluten. Non celiac gluten syndrom (NCGS) is a disorder diagnosed when celiac disease and wheat allergy are eliminated as possible cause of gastrointestinal symptoms caused by ingestion of gluten. The aim of this study was to evaluate dietary habits, nutritional status and quality of life of ambulant patients of University Hospital Centre Zagreb – Rebro whose diagnosis of celiac disease or NCGS was reached in adulthood. Study was performed with antropometric and dietetic methods and laboratory testing. Dietary record was done by 21 patients suffering from celiac disease and by 7 patients suffering from NCGS. In average patients have adequate body mass and low risk of malnutrition, however, group with celiac disease has higher body mass index (BMI) values and, according to CDQOL (Celiac Disease Quality of Life) form, better quality of life. Furthermore, according to histological findings almost all newly diagnosed patients who suffer from celiac disease have lesions of Marsh 3 type (villous atrophy) but in patients who adhere to the strict gluten-free diet, the condition is usually normalized in one year. In the group with NCGS small-bowel mucose damage was not found. Patients with celiac disease who follow gluten-free diet normalized their serologic parameter: tTG IgA antibodies values.

• Keywords: celijakija; NCGS; bezglutenska prehrana; nutritivni status; kvaliteta života
• Keywords (english): celiac disease; NCGS; gluten-free diet; nutritional status; quality of life
• Language: croatian
• URN:NBN: urn:nbn:hr:159:577312
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-12-03 10:13:21