Proizvodnja cjepiva protiv gripe tehnologijom životinjskih stanica

undergraduate thesis

• Title (english): Animal cell technology in influenza vaccine production
• Author: Ena Buljubašić
• Mentor: Igor Slivac (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Cell Technology, Application and Biotransformations); Zagreb
• Defense date and country: 2020-09-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Gripa (ili influenca) je virusna, infektivna i respiratorna bolest koja godišnje zarazi do milijardu ljudi diljem svijeta. Pojavljuje se svake godine kao sezonska bolest, no u povijesti se svakih nekoliko desetaka godina javljala i kao pandemija. Njezin nepovoljan učinak na pojedinca i društvo može se spriječiti upotrebom cjepiva, tj. cijepljenjem. Prvo odobreno cjepivo protiv gripe proizvedeno je u embrioniranom kokošjem jajetu prije skoro 80 godina, a po sličnom tehnološkom načelu proizvode se i današnja cjepiva. Znanstveni napredak u razumijevanju stanične biologije te unaprjeđenje proizvodnih postupaka pomoću životinjskih stanica omogućilo je procesnim biotehnolozima prijelaz s konvencionalnih na nove, produktivnije i brže proizvodne postupke. U radu će se razmotriti epidemiologija gripe, struktura virusa gripe te proizvodnja virusnih cjepiva i cjepiva protiv gripe. Cilj rada je prikazati trenutačne trendove i potrebe u proizvodnji cjepiva protiv gripe, s osobitim naglaskom na proizvodnju u staničnim kulturama.

Abstract (english)

Influenza (flu) is a viral, contagious, respiratory disease that annually infects up to a billion people worldwide. It appears each year as a seasonal disease, but through history, it appeared as pandemic illness once in every several decades. Its harmful effects on human health and consequently to the society can be prevented by vaccination. The first approved influenza vaccine was made almost 80 years ago using embryonated hen eggs and the same technology is still in use for most available vaccines today. The development of cell biology and improvement of cell culture manufacturing techniques enabled the transition from conventional to novel, more efficient vaccine production methods. In this thesis, the epidemiology of influenza, influenza virus structure and the viral vaccine manufacturing is described. The main goal here is to introduce current trends and challenges in influenza vaccine production, as well as to emphasize the importance of animal cell technology in this process.

• Keywords: virusna cjepiva; gripa; stanična kultura
• Keywords (english): viral vaccines; influenza; cell cultures
• Language: croatian
• URN:NBN: urn:nbn:hr:159:093007
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-16 10:38:31