Utjecaj strukturne modifikacije na antimikrobnu aktivnost kurkuminskih derivata

undergraduate thesis

• Title (english): The effect of structural modifications on the antimicrobial activity of curcumin derivatives
• Author: Marina Marić
• Mentor: Veronika Kovač (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2020-09-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Kurkumin, polifenolni spoj prisutan u korijenu biljke Curcuma longa, posjeduje razna farmakološka svojstva, kao što je primjerice antimikrobna aktivnost. Kako je iskorištenje kurkumina u organizmu izrazito nisko, provedena su brojna istraživanja u svrhu poboljšanja njegove bioraspoloživosti. Ozbiljnu prijetnju javnom zdravstvu danas predstavlja mikrobiološka rezistencija na antibiotike pa se javila potreba za zamjenom konvencionalnih antibiotika drugim agensima, primjerice otkrivanjem novih, biološki aktivnijih i biodostupnijih spojeva kurkumina. U ovom je radu prikazano kako strukturna modifikacija utječe na antimikrobnu aktivnost različitih kurkuminskih derivata in vitro, a da bi se evaluirala aktivnost sintetiziranih spojeva in vivo, potrebne su daljnje studije.

Abstract (english)

Curcumin, polyphenolic compound present in the root of a plant Curcuma longa, possesses various pharmacological properties, such as antimicrobial activity. Due to curcumin's very low yield in organism, numerous studies were conducted to increase its bioavailability. Today microbiological resistance to antibiotics poses a serious threat to public health so there is the need to replace conventionally used antibiotics with other agents, for instance by discovering new, biologically more active and bioavailable compounds of curcumin. In this thesis it is shown how structural modification impacts antimicrobial activity of various curcumin derivatives in vitro, but in order to evaluate the activity of synthesized compounds in vivo, further studies are needed.

• Keywords: antimikrobna aktivnost; kurkumin; kurkuminski derivati; mikrobna rezistencija
• Keywords (english): antimicrobial activity; curcumin; curcumin derivatives; microbial resistance
• Language: croatian
• URN:NBN: urn:nbn:hr:159:461982
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-10-26 13:00:13