Nutritivna potpora oboljelima od zloćudnog tumora debelog crijeva

undergraduate thesis

• Title (english): Nutritional support of patients with malignant tumors of colon
• Author: Elena Dujmić
• Mentor: Željko Krznarić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Nutrition Science); Zagreb
• Defense date and country: 2014-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Rak debelog crijeva jedan je od vodećih zdravstvenih problema u svijetu. U radu se želi naglasiti važnost ranog prepoznavanja i liječenja tumorske kaheksije kod bolesnika oboljelih od zloćudnih tumora debelog crijeva. Kaheksija nastaje zbog neadekvatnog unosa energije, povećane potrošnje energije, promijenjenog metabolizma i abnormalnosti izazvanih lučenjem proinflamatornih citokina. Nutritivna potpora je nužna kako bi smanjila posljedice odbijanja hrane te kako bi poboljšala antitumorsku terapiju i kvalitetu života. Preferira se upotreba enteralne prehrane u odnosu na parenteralnu. Postoperativna enteralna prehrana može značajno skratiti boravak u bolnici te ima tendenciju smanjenja postoperativnih komplikacija. Parenteralna prehrana se primjenjuje kod ozbiljno pothranjenih bolesnika kod kojih se enteralna prehrana ne može adekvatno davati oralno ili enteralno. Primjena megestrol-acetata i enteralne prehrane s povišenim unosom EPA-e u trajanju od najmanje 8 tjedana poželjna je terapijska kombinacija.

Abstract (english)

Colorectal cancer is one of the leading health problems in the world. In this thesis the emphasis is on the importance of early recognition and treatment of cancer cachexia in patients with malignant tumors of the colon. Cachexia occurs due to inadequate energy intake, increased energy expenditure, altered metabolism, and abnormalities induced secretion of proinflammatory cytokines. Nutritional support is essential in order to minimize the consequences of food refusal and to enhance the anti-tumor therapy and quality of life. Enteral nutrition is preferable rather then parenteral. Postoperative enteral nutrition can significantly shorten hospital stays and tends to decrease postoperative complications. Parenteral nutrition is indicated in severely malnourished patients in whom enteral nutrition can not be adequately administered orally or enterally. Use of megestrol acetate and enteral nutrition with high intake of EPA of at least 8 weeks is a preferable therapy.

• Keywords: rak debelog crijeva; tumorska kaheksija; nutritivna potpora; enteralna prehrana; parenteralna prehrana
• Keywords (english): colorectal cancer; cancer cachexia; nutritional support; enteral nutrition; parenteral nutrition
• Language: croatian
• URN:NBN: urn:nbn:hr:159:997324
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-04-26 13:40:19