The impact of diet on intestinal microbiota of paediatric patients with inflammatory bowel disease

doctoral thesis

• Title (croatian): Utjecaj prehrane na crijevnu mikrobiotu u pedijatrijskih bolesnika s upalnim bolestima crijeva
• Author: Sara Sila
• Mentor: Iva Hojsak (mentor)
• Committee member: Irena Colić-Barić (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Nutrition Science); Zagreb
• Defense date and country: 2020-10-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

The diet has a profound effect on the gut microbiota and development of inflammatory bowel disease (IBD). Characteristics of the gut microbiota were determined in children with IBD at the time of diagnosis and on the 2nd and the last day of exclusive enteral nutrition (EEN). Children with IBD demonstrate significant differences in dietary intake (lower intake of energy, calcium and fruits) and lower lean mass-for-age z-scores at diagnosis. Moreover, lower abundance of the phylum Firmicutes and higher abundance of the phylum Proteobacteria was observed in patients compared to healthy siblings and healthy controls at the time of diagnosis. EEN leads to similar changes in the microbiota composition in children with CD and their healthy siblings.

Abstract (croatian)

Prehrana ima značajan utjecaj na crijevnu mikrobiotu i razvoj kroničnih upalnih bolesti crijeva (IBD). Karakteristike crijevne mikrobiote u djece s IBD-om određene su u vrijeme dijagnoze, te na drugi i posljednji dan isključive enteralne prehrane (EEN). Djeca s IBD-om pokazuju značajnu razliku u prehrambenom unosu (niži unos energije, kalcija i voća), te niži z-score za nemasnu tjelesnu masu u vrijeme dijagnoze u usporedbi sa zdravim kontrolama. Nadalje, utvrdili smo manju zastupljenost bakterija iz reda Firmicutes, te veću zastupljeno iz reda Proteobacteria kod djece s IBD-om u vrijeme dijagnoze. EEN dovodi do sličnih promjena u sastavu mikrobiote u djece sa CD-om i njihovih zdravih braće i sestara.

• Keywords: children; diet; exclusive enteral nutrition; gut microbiota; inflammatory bowel disease
• Keywords (croatian): crijevna mikrobiota; djeca; isključiva enteralna prehrana; prehrana; upalne bolesti crijeva
• Language: english
• URN:NBN: urn:nbn:hr:159:873553
• Study programme: Title: Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor znanosti/doktorica znanosti (doktor znanosti/doktorica znanosti)
• Type of resource: Text
• Extent: 167 str. : 30 cm
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-02-18 11:43:27