Primjena spektrometrije masa u analizi biljnih pripravaka s ciljem pronalaska ilegalnih farmaceutski aktivnih tvari

undergraduate thesis

• Title (english): Mass spectrometric analysis of illegal pharmaceutical adulterants in botanical dietary supplements and herbal remedies
• Author: Anamarija Vrabec
• Mentor: Anita Horvatić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Physical Chemistry and Corrosion); Zagreb
• Defense date and country: 2021-09-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Zbog sve veće potražnje za biljnim dodacima prehrani, kao i biljnim lijekovima, porastao je i broj njihovih ilegalnih, neodobrenih te zabranjenih sastojaka, kao što su inhibitori fosforodiesteraze tipa 5 (PDE-5), anabolički steroidi te hipoglikemična i antihipertenzivna sredstva. Interakcija s drugim lijekovima te prekomjerna i nepravilna upotreba mogu uzrokovati nuspojave kao što su srčani ili moždani udar, halucinacije, tahikardija, povraćanje, grčevi i uzrujanost. Praćenjem proizvodnje i... More razvoja biljnih pripravaka žele se zaštiti zdravlje i sigurnost potrošača. Neke od metoda koje se koriste u kontroli kvalitete ovih proizvoda su tekućinska kromatografija-spektrometrija masa (LC-MS) i plinska kromatografija-spektrometrija masa (GC-MS). Ovaj rad će se pobliže dotaknuti same tehnike spektrometrije masa (MS) kao i njene primjene u analizi biljnih pripravaka s ciljem pronalaska ilegalnih farmaceutski aktivnih tvari. Less

Abstract (english)

Due to the high demand for botanical dietary supplements and herbal remedies, there is an increase in illegal, unapproved and prohibited ingredients such as phosphodiesterase type 5 (PDE-5) inhibitors, anabolic steroids, hypoglycemic and antihypertensive agents adulterated within these products. Interaction with other medications, overuse and misuse can lead to serious side effects, such as heart attack, hallucinations, tachycardia, vomiting, convulsions, agitation and seizures. Monitoring... More the development of these products will ensure the health and safety of consumers. Some of the analytical techniques used for the aforementioned monitoring are liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC–MS). This thesis will address mass spectrometry (MS) and its application in the analysis of botanical dietary supplements and herbal remedies in order to detect illegal pharmaceutical adulterants. Less

• Keywords: biljni dodaci prehrani; biljni pripravci; krivotvorine; LC-MS; spektrometrija masa
• Keywords (english): botanic dietary supplements; herbal remedies; mass spectrometry; LC-MS; pharmaceutical adulterants
• Language: croatian
• URN:NBN: urn:nbn:hr:159:419932
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-09-27 09:55:32