Potencijalno bioaktivno djelovanje ksantohumola – preniliranog flavonoida hmelja (Humulus lupulus L.)

master's thesis

• Title (english): Potential bioactive effect of xanthohumol prenylated flavonoid from hops (Humulus lupulus L.)
• Author: Paula Mišković
• Mentor: Teuta Murati (mentor)
• Committee member: Ivana Kmetič (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Toxicology); Zagreb
• Defense date and country: 2022-04-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Biljka Humulus lupulus L., odnosno njene šišarice, izlučuju lupulin, cvjetni prah bogat različitim bioaktivnim kemijskim spojevima te karakterističnom skupinom spojeva, preniliranim flavonoidima. Najvažniji i najzastupljeniji prenilirani halkon je bioaktivni spoj ksantohumol (KSN). U ovom radu dan je pregled mehanizama djelovanja KSN-a koja uključuju imunomodulatorno, antiproliferativno, citotoksično, antiangiogeno, antioksidacijsko, antigenotoksično, antimikrobno i antiviralno djelovanje. KSN uspješno inhibira rast tumora i angiogenezu te inducira apoptozu tumorskih stanica u in vitro i in vivo modelima. Bioaktivnost KSN-a i snažno antitumorsko djelovanje ukazuju na mogući terapijski potencijal ovog spoja te potrebu za daljnjim istraživanjima.

Abstract (english)

The hop cones of the plant Humulus lupulus L. secrete lupulin, a resinous powder rich in various bioactive compounds with characteristic group of compounds, prenylflavonoids. The most important prenylated chalcone is bioactive compound xanthohumol (XN). This review shows mechanisms of actions of XN including immunomodulatory, antiproliferative, cytotoxic, antiangiogenic, antioxidant, antigenotoxic, antimicrobial and antiviral activity. XN successfully inhibits tumor growth and angiogenesis and induces tumor cell apoptosis in in vitro and in vivo models. Bioactivity and strong antitumor activity of XN indicate a possible therapeutic potential of this compound and the need for further studies.

• Keywords: ksantohumol; hmelj; bioaktivni spojevi; tumor; mehanizam djelovanja
• Keywords (english): xanthohumol; hops; bioactive compounds; tumor; mode of action
• Language: croatian
• URN:NBN: urn:nbn:hr:159:138166
• Study programme: Title: Food Engineering; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka prehrambenog inženjerstva (magistar/magistra inženjer/inženjerka prehrambenog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-27 10:10:15