Analiza matematičkog modela regulacije metabolizma glukoze

master's thesis

• Title (english): Analysis of a mathematical model of glucose metabolism regulation
• Author: Dora Gošev
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Committee member: Maja Benković (član povjerenstva)
• Committee member: Ivana Rumora Samarin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2022-09-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

U ovom radu provedena je računalna analiza modela metabolizma glukoze primjenom programskog paketa CellDesigner. Provedene su simulacije modela s različitim početnim koncentracijama glukoze i inzulina, koje su ovisile o konzumiranom obroku. U tu svrhu osmišljena su 3 jelovnika: jelovnik za dijabetičare, jelovnik s malim udjelom ugljikohidrata i jelovnik za opću populaciju. Rezultati pokazuju najveće skokove, kao i padove, kod obroka koji su bogati glukozom, dok su obroci iz jelovnika za dijabetičare imali postupan pad do bazalne vrijednosti glukoze. Također je provedena analiza lokalne parametarske osjetljivosti kako bi se identificirali najosjetljiviji metaboliti modela. Rezultati ističu važnost inzulina u regulaciji glukoze i održavanju vrijednosti glukoze u krvi unutar referentnih vrijednosti. Korišteni model uspješno simulira metabolizam glukoze za odabrani raspon početnih vrijednosti.

Abstract (english)

Computer analysis of the glucose metabolism model was performed using the CellDesigner software package. Simulations of the models were conducted, each of them having different glucose and insulin values, depending on a consumed meal. For that purpose, three different menus were made: a menu for diabetics, a menu containing low amounts of carbohydrates and a menu for general population. Results show the biggest jumps, as well as drops, for meals that are high in glucose, while meals made for diabetics show a gradual decline in basal glucose values. Analysis of local parameter sensibility was also conducted to identify the most sensitive metabolite. The results of simulations indicate the importance of hormone insulin in glucose regulation and maintaining blood glucose values in a healthy range. Model that was used successfully simulates glucose metabolism for selected range of initial values.

• Keywords: metabolizam glukoze; matematički model; analiza lokalne osjetljivosti; CellDesigner
• Keywords (english): glucose metabolism; mathematical model; local sensitivity analysis; CellDesigner
• Language: croatian
• URN:NBN: urn:nbn:hr:159:793012
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-02-22 08:44:04