Uloga tumor supresorskih gena BRCA2 i TP53 u razvoju karcinoma dojke

undergraduate thesis

• Title (english): Function of the tumor suppressor genes BRCA2 and TP53 in breast cancer development
• Author: Ivana Buršić
• Mentor: Reno Hrašćan (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2014-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Rak dojke je jedan od najčešćih tumora koji zahvaća žene diljem svijeta. Glavni uzrok nastanka raka je gubitak kontrole normalnog rasta stanica. Jedna od nekoliko grupa gena koji imaju značajnu ulogu u razvoju karcinoma su tumor supresorski geni. Oni kodiraju za proteine koji djeluju kao negativni regulatori rasta tumora te u normalnim uvjetima inhibiraju proliferaciju stanica ili usporavaju diobu. Mutacije u tumor supresorskim genima koje inaktiviraju njihovo inhibicijsko djelovanje... More dopridonose razvitku raka. U ovom radu su prikazane različite strukturne promjene u tumor supresorskim genima BRCA2 i TP53 i njihov utjecaj na razvoj karcinoma dojke. Less

Abstract (english)

Breast cancer is the most common cancer in women worldwide. Cancer arises from a loss of normal growth control. A group of genes that are important for cancer development are the tumor suppressor genes. Those genes encode proteins that normally inhibit the formation of tumors. Their normal function is to inhibit cell proliferation, or slow down cell division. Mutations in tumor suppressor genes contribute to the development of cancer by inactivating that inhibitory function. In this... More study structural changes in the tumor suppressor genes BRCA2 and TP53 and their function in breast cancer development were observed. Less

• Keywords: karcinom dojke; tumor supresorski geni; BRCA2 gen; TP53 gen
• Keywords (english): breast cancer; tumor suppressor genes; BRCA2 gene; TP53 gene
• Language: croatian
• URN:NBN: urn:nbn:hr:159:002914
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-04-27 10:19:26