Utjecaj prehrane na inzulinsku rezistenciju u žena sa sindromom policističnih jajnika

undergraduate thesis

• Title (english): The impact of diet on insulin resistance in women with polycystic ovary syndrome
• Author: Katarina Lončarić
• Mentor: Ivana Rumora Samarin (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Food Chemistry and Biochemistry); Zagreb
• Defense date and country: 2023-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Sindrom policističnih jajnika (PCOS), karakteriziran ovulacijskim poremećajima, hiperandrogenizmom i policističnom morfologijom jajnika je najčešći metabolički i endrokrini poremećaj žena reproduktivne dobi. Uz povećane rizike od razvoja dijabetesa tipa 2 i kardiovaskularnih bolesti, većina žena s PCOS-om ima inzulinsku rezistenciju, nemogućnost organizma da učinkovito reagira na inzulin, te povećanu prevalenciju pretilosti. Inzulinska rezistencija i hiperandrogenizam kao simptomi PCOS-a, povezani su te se međusobno pogoršavaju pri čemu hiperinzulinemija doprinosi povišenom lučenju androgena koji povratno pogoršavaju inzulinsku rezistenciju. Neadekvatna prehrana ključan je čimbenik u razvoju pretilosti i inzulinske rezistencije kod žena s PCOS-om, a povezano s time su dane opće preporuke za pacijentice s PCOS-om u vidu smanjenja ukupnog energijskog unosa, povećanja raznolikosti prehrane te tjelesne aktivnosti. Mediteranska, ketogena, DASH i dijeta s niskim glikemijskim indeksom spadaju u najčešće predložene obrasce prehrane za žene s ovim sindromom zbog dokazanih pozitivnih učinaka na gubitak tjelesne mase, indeks tjelesne mase, koncentraciju inzulina te indeks inzulinske rezistencije.

Abstract (english)

Polycystic ovary syndrome (PCOS), characterized by ovulatory disorders, hyperandrogenism, and polycystic ovarian morphology, is the most common metabolic and endocrine disorder in women of reproductive age. Along with increased risks of developing type 2 diabetes and cardiovascular diseases, most women with PCOS have insulin resistance, which is the body's inability to effectively respond to insulin, and a higher prevalence of obesity. Insulin resistance and hyperandrogenism in PCOS have a bidirectional relationship, where hyperinsulinemia contributes to increased androgen secretion, which in turn worsens insulin resistance. Inadequate nutrition is a key factor in the development of obesity and insulin resistance in women with PCOS, and general recommendations for PCOS patients include reducing energy intake and increasing the variety of diet and physical activity. Mediterranean, ketogenic, DASH, and low glycemic index diet are among the commonly suggested diets for women with PCOS, with proven positive effects on weight loss, body mass index, insulin levels, and insulin resistance index.

• Keywords: sindrom policističnih jajnika; inzulinska rezistencija; prehrana; pretilost
• Keywords (english): polycystic ovary syndrome; insulin resistance; diet; obesity
• Language: croatian
• URN:NBN: urn:nbn:hr:159:127856
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-24 11:26:30