Epigenske odrednice karcinoma

undergraduate thesis

• Title (english): Epigenetic determinants of carcinoma
• Author: Ana Udženija
• Mentor: Lidija Šver (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2023-09-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Epigenetika je grana biologije koja proučava nasljedne promjene u ekspresiji gena bez promjena na DNA sekvenci. Epigenske promjene ključne su za normalni razvoj i zdravlje, koje održavaju pomoću metilacije DNA, modifikacije histona i djelovanjem nekodirajućih RNA molekula. Epigenski poremećaji imaju veliki utjecaj na razvoj karcinoma jer osiguravaju progresiju karcinoma utišavanjem ekspresije tumor-supresorskih gena i gena za popravak DNA te aktiviranjem ekspresije onkogena. Epigenski mehanizmi djeluju istovremeno, u kombinaciji jedni s drugima te u kombinaciji s genskim promjenama. Za razliku od genskih promjena, epigenske promjene pružaju velik potencijal za razvijanje terapija, s obzirom na to da su reverzibilne.

Abstract (english)

Epigenetics is a branch of biology that studies heritable changes in gene expression made without changes in DNA sequence. Such changes are seen in e.g. normal development and health, which are maintained through DNA methylation, histone modifications, and the action of non-coding RNA molecules. Epigenetic disruptions have a significant impact on the carcinoma development, driving carcinoma progression by silencing the expression of tumor suppressor and DNA repair genes, while activating the expression of oncogenes. Epigenetic mechanisms act simultaneously, in combination with each other, and in conjunction with genetic alterations. Epigenetic alterations hold significant potential for therapeutic development because, unlike genetic alterations, they are reversible.

• Keywords: epigenetika; karcinom; DNA metilacija; histonske modifikacije; nekodirajuće RNA
• Keywords (english): epigenetic; cancer; DNA methylation; histone modification; non-coding RNA
• Language: croatian
• URN:NBN: urn:nbn:hr:159:090829
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-30 11:24:50