Simulacija modela kinetike glukoze i inzulina primjenom glikemijskog opterećenja miješanih obroka

master's thesis

• Title (english): Simulation of glucose and insulin kinetics model using the glycemic load of mixed meals
• Author: Sara Maraš
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Committee member: Maja Benković (član povjerenstva)
• Committee member: Ivana Rumora Samarin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2023-12-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Cilj ovog rada bio je ispitati utjecaj glikemijskog opterećenja svakog miješanog obroka na koncentraciju glukoze i inzulina korištenjem matematičkog modela kinetike glukoze i inzulina u programskom paketu WR Mathematica. Glikemijsko opterećenje određeno je pomoću tri različita jelovnika (visoko ugljikohidratni, dijabetički i nisko ugljikohidratni jelovnik) koji su razvijeni u tu svrhu. Rezultati su pokazali da jelovnik s visokim glikemijskim opterećenjem ima veliki utjecaj na razinu glukoze i inzulina u krvi. Postotak ugljikohidrata i bjelančevina (r = -0,9500), kao i postotak ugljikohidrata i masti (r = -0,9855) u jelovnicima su u negativnoj korelaciji. Uzimajući sve u obzir, glikemijsko opterećenje jednog obroka može se koristiti kao početna točka za modeliranje metabolizma glukoze-inzulina. Korištenje modela metabolizma glavnih nutrijenata omogućuje prilagođeni pristup planiranju obroka, a za osobe s dijabetesom dijeta s niskim glikemijskim opterećenjem pokazala se korisnom.

Abstract (english)

The aim of the study wasto examine the effect of each mixed meal's glycemic load on glucose and insulin concentration using a mathematical model of glucose and insulin kinetics in WR Mathematica software package. Glycemic load was determined using three different menus (low-carb, diabetic, and high-carb menus) that were developed for this purpose. The results showed that the high-glycemic load menu has a major effect on insulin and blood glucose levels. The percentage of carbs and proteins (r = - 0.9500), as well as the percentage of carbs and fats (r = -0.9855) in the menus are negatively correlated. All things considered, the glycemic load of a single meal can be utilized as a starting point for modeling the metabolism of glucose and insulin. Using the main nutrient metabolism model enables a customized approach to meal planning, and for individuals with diabetes, a low-glycemic-load diet has been shown beneficial.

• Keywords: sistemska biologija u nutricionizmu; model kinetike glukoze i inzulina; glikemijsko opterećenje; dijabetes tip 1
• Keywords (english): systems biology in nutrition; model of glucose and insulin kinetics; glycemic load; type 1 diabetes
• Language: croatian
• URN:NBN: urn:nbn:hr:159:572246
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-05-29 13:36:27