Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu

master's thesis

• Title (english): Simulation and analysis of global parameter sensitivity of the carbohydrate decomposition model in the colon
• Author: Ines Pranjić
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Committee member: Maja Benković (član povjerenstva)
• Committee member: Ivana Rumora Samarin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2023-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Pravilnom prehranom organizam se opskrbljuje svim potrebnim nutrijentima koji, kroz različite biokemijske procese, osiguravaju stanicama rast i normalno funkcioniranje. Metabolizam ugljikohidrata pomoću mikrobiote debelog crijeva jedan je od tih procesa čiji se model analizirao u ovome radu. U svrhu toga, razvijena su četiri jelovnika sa različitim početnim koncentracijama laktoze i glukoze. Model je simuliran u vremenskom intervalu od pet dana i pritom je praćena promjena koncentracije laktoze, glukoze, butirata, polisaharida i mikroorganizama koji koriste laktozu i glukozu. Rezultati pokazuju da se promjenom početne koncentracije laktoze značajno mijenjala i dinamika razgradnje laktoze u debelom crijevu čovjeka. Budući da je riječ o biološkom sustavu, provedena je analiza i globalne parametarske osjetljivosti. Kao najosjetljiviji kinetički parametar istaknula se maksimalna specifična brzina hidrolize polisaharida u jednostavne šećere, khyd,z. U pozadini cijele simulacije je tendencija razvoja individualizirane prehrane odnosno, koncepta skrojenog prema prehrambenim potrebama pojedinca.

Abstract (english)

With a proper diet, the body is supplied with all the necessary nutrients that, after undergoing various biochemical processes, ensure the growth and normal functioning of the cells. Carbohydrate metabolism by colon microbiota is one of those processes whose model was analyzed in this thesis. For this purpose, four menus were developed with different initial concentrations of lactose and glucose. The model was simulated in a time interval of five days and the change in the concentration of lactose, glucose, butyrate, polysaccharides and microorganisms that use lactose and glucose was monitored. The results show that by changing the initial concentration of lactose, the dynamics of lactose decomposition in the human colon also changed significantly. Since it is a biological system, an analysis of global parametric sensitivity was also performed. The maximum specific rate of hydrolysis of polysaccharides (khyd,z) stood out as the most sensitive kinetic parameter. In the background of the entire simulation is the tendency to develop individualized nutrition, a concept tailored to the nutritional needs of the individual.

• Keywords: metabolizam ugljikohidrata; laktoza; matematički model; globalna parametarska osjetljivost
• Keywords (english): carbohydrate metabolism; lactose; mathematical model; global parameter sensitivity
• Language: croatian
• URN:NBN: urn:nbn:hr:159:617582
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-02 09:21:20