Uloga vitamina D u regulaciji inzulinske rezistencije kod osoba oboljelih od Hashimotovog tireoiditisa

undergraduate thesis

• Title (english): The role of vitamin D in the regulation of insulin resistance in patients with Hashimoto's thyroiditis
• Author: Karla Mandurić
• Mentor: Ivana Rumora Samarin (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Food Chemistry and Biochemistry); Zagreb
• Defense date and country: 2024-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Hashimotov tireoiditis je autoimuna bolest koja uzrokuje napad imunološkog sustava na stanice štitne žlijezde, dovodeći do hipotireoze. Inzulinska rezistencija je stanje povezano s pretilošću pri kojem inzulin ne može učinkovito obavljati svoje funkcije, što može dovesti do dijabetesa tipa 2 i drugih komplikacija. Poznato je da je vitamin D ključan za zdravlje kostiju, ali također vrlo važnu ulogu ima u moduliranju imunoloških funkcija i održavanju metaboličkog zdravlja Cilj ovog rada je pregledom dostupne znanstvene literature istražiti učinkovitost vitamin D na inzulinske rezistencije i Hashimotovog tireoiditisa te na poboljšanje kvalitete života oboljelih. U navedenu svrhu pretražene su baze podataka „Web of Science“ i „PubMed“ pretragom ključnih riječi obuhvaćenih u ovom radu. Rezultati većine pregledanih radova ukazuju da nedostatak vitamina D može doprinijeti razvoju inzulinske rezistencije, osobito kod oboljelih od Hashimotovog tireoiditisa te da suplementacija vitaminom D, u nekim slučajevima, može poboljšati osjetljivost na inzulin i smanjiti rizik od dijabetesa tipa 2. Zbog nekonzistentnosti rezultata potrebna su daljnja istraživanja za određivanje optimalnih doza i trajanja suplementacije.

Abstract (english)

Hashimoto's thyroiditis is an autoimmune disease in which the immune system attacks the cells of the thyroid gland, leading to hypothyroidism. Insulin resistance is an obesity-related condition in which insulin cannot fulfil its functions effectively, which can lead to type 2 diabetes and other complications. Vitamin D is known to be crucial for bone health, but it also plays a very important role in modulating immune functions and maintaining metabolic health. The aim of this work is to review the available scientific literature to investigate the effectiveness of vitamin D in treating symptoms of insulin resistance in patients with Hashimoto's thyroiditis and improving quality of life. For this purpose, the databases "Web of Science" and "PubMed" were searched for the keywords contained in this article. Most results suggest that vitamin D deficiency may contribute to the development of insulin resistance, particularly in patients with Hashimoto's thyroiditis, and that vitamin D supplementation may in some cases improve insulin sensitivity and reduce the risk of type 2 diabetes. Due to the inconsistent results, further research is needed to determine the optimal dose and duration of supplementation.

• Keywords: vitamin D; inzulinska rezistencija; Hashimoto tireoiditis
• Keywords (english): vitamin D; insulin resistance; Hashimoto thyroiditis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:435355
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-09-11 08:55:40