Učinak masnih kiselina iz ribljeg ulja na imunosni sustav i reumatoidni artritis

undergraduate thesis

• Title (english): The effect of fatty acids from fish oil on the immune system and rheumatoid arthritis
• Author: Katarina Hunjet
• Mentor: Lidija Šver (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2013-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

U radu su objašnjeni mogući utjecaji dugolančanih polinezasićenih masnih kiselina (prema engl. polyunsaturated fatty acids; PUFA) na zdravlje ljudi, primarno u smislu upalnih odgovora, utjecaju na funkcije T-limfocita, produkciju citokina te utjecaj na membransku fluidnost i smrtnost stanica. Nizak unos ribljeg ulja (5%), za razliku od visokog unosa (25%) ima pozitivne učinke na upalne bolesti ljudi. Suplementacija 18 g/dan/6 tjedana smanjila je proliferaciju T-limfocita povezano s redukcijom u sekreciji interleukina-2, stimuliranih fitohemaglutininom. Omega-3 masne kiseline ili inhibiraju ili nemaju utjecaj na imunosni odgovor. Velike koncentracije eikosapentaenske i dokosaheksaenske kiseline inhibiraju funkcije neutrofila i monocita, ovisno o konzumiranoj količini vitamina E, također smanjuju i proupalnu funkciju citokina. PUFA masne kiseline povećavaju fluidnost membrane što rezultira smrtnošću stanice. omega-6 su u tom području utjecajnije od omega-3 masnih kiselina (izuzetak je linolna kiselina, LNA).

Abstract (english)

This paper deals with the possible impacts of long-chain polyunsaturated fatty acids (PUFA) on human health, primarily in terms of inflammatory responses, the function of T-cells, cytokine production and on membrane fluidity and cell mortality. Low intake of fish oil (5%), in contrast to the high intake (25%) has positive effects on inflammatory human diseases. Supplementation of 18 g/day/6 weeks decreased the proliferation of T-cells associated with a reduction in the secretion of interleukin-2, phytohemagglutinin-stimulated. Omega-3 fatty acids either inhibit or have no effect on the immune response. Large concentrations of eicosapentaenoic and docosahexaenoic acid inhibit the function of neutrophils and monocytes, depending on the amount of vitamin E consumed, and also reduce the pro-inflammatory cytokine function. PUFA fatty acids increase the fluidity of the membrane, resulting in increased cell death rate. omega-6 fatty acids are more influential in that area then omega-3 fatty acids (an exception is linoleic acid, LNA).

• Keywords: T-limfocite; citokini; riblje ulje; EPA; DHA
• Keywords (english): T-cells; cytokines; fish oil; EPA; DHA
• Language: croatian
• URN:NBN: urn:nbn:hr:159:595382
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-04 07:48:50