Mikrosatelitna nestabilnost i gubitak heterozigotnosti u glioblastoma

undergraduate thesis

• Title (english): Microsatellite instability and loss of heterozygosity in glioblastoma
• Author: Ivana Gunčić
• Mentor: Reno Hrašćan (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2016-06-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

U ovom radu govorit ću o dvije genske promjene u glioblastoma i njihovom utjecaju na proces kancerogeneze. Riječ je o gubitku heterozigotnosti (LOH) i mikrosatelitnoj nestabilnosti (MSI). Cilj je iznijeti teorijsku pozadinu i sumirati neka od dosadašnjih istraživanja u području glioblastoma za navedene nestabilnosti. Naime, njihova pojava i učestalost varira u promatranim istraživanjima, no svakako doprinose genomskoj nestabilnosti. Daju uvid u genske promjene uključene u razvoj (i vraćanje) glioblastoma. Funkciju MSI teško je definirati i pretpostavlja se da je manje važan čimbenik pri razvoju glioblastoma, dok je LOH dokazano bitan čimbenik. Također, obje promjene služe kao markeri za bolje predviđanje progresije bolesti i ishoda preživljavanja. Može se zaključiti kako ove pojave i slični mehanizmi predstavljaju područje interesa u budućim istraživanjima glioblastoma.

Abstract (english)

This paper is based on two genetic changes in glioblastoma and their impact on the process of carcinogenesis: the loss of heterozygosity (LOH) and microsatellite instability (MSI). The aim is to present theoretical background and summarize some of the current research in the field of glioblastoma for specified instabilities. Their occurrence and frequency varies in observed studies, but they surely contribute to genomic instability. They provide insight into the genetic changes involved in the development (and recurrence) of glioblastoma. MSI function is difficult to determine and it is assumed to be a less important factor for developing glioblastoma, while LOH has proven to be a significant factor. In addition, both can be used as markers to predict disease progression and mortality rate. Therefore, these phenomena and similar mechanisms represent a promising area for future glioblastoma research.

• Keywords: glioblastom; mikrosatelitna nestabilnost; gubitak heterozigotnosti
• Keywords (english): glioblastoma; microsatellite instability; loss of heterozygosity
• Language: croatian
• URN:NBN: urn:nbn:hr:159:484319
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-04-21 12:13:40