Utjecaj biljnih dodataka prehrani sa vazodilatacijskim učinkom na pojavu oksidacijskog stresa u Swiss albino miša

master's thesis

• Title (english): Effect of vasodilatative herbal supplements on the occurrence of oxidative stress in Swiss albino mice
• Author: Jelena Tomić
• Mentor: Irena Landeka Jurčević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Food Chemistry and Biochemistry); Zagreb
• Defense date and country: 2013-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Erektilna disfunkcija široko je rasprostranjeni poremećaj, a predviđanja su kako će se broj oboljelih u skoroj budućnosti umnogostručiti. Budući da je erekcija vaskularni proces, erektilna disfunkcija smatra se ranim simptomom kardiovaskularne bolesti, prije nego njezinom posljedicom. Podražaj inducira otpuštanje dušikovog oksida u corpora cavernosa penisa te dolazi do produkcije cGMP-a, glavnog čimbenika relaksacije glatkog mišića, uslijed kojeg nastupa erekcija. U liječenju erektilne disfunkcije koriste se inhibitori fosfodiesteraze 5, enzima ključnog za degradaciju cGMP-a. Zbog kontraindikacija s određenim lijekovima koji se koriste u terapiji KVB, biljni dodaci prehrani postaju perspektivna alternativa PDE 5 inhibitorima. Ovaj rad istražio je utjecaj biljnih dodataka prehrani na pojavu oksidacijskog stresa u tkivu jetre, bubrega i testisa Swiss albino miša. Indikatori oksidacijskog stresa bili su aktivnost superoksid dismutaze (SOD) te koncentracije reduciranog glutationa (GSH) i malondialdehida (MDA). U odnosu na kontrolu, aktivnosti SOD i GSH statistički značajno su smanjene (p<0,05) kod dva ispitivana suplementa, dok je koncentracija MDA značajno povećana (p<0,05) u tri ispitivana dodatka prehrani.

Abstract (english)

Erectile dysfunction (ED) is a widespread disorder. The prevalence of ED is expected to increase considerably in the future. Since erection is a vascular process, ED is considered to be an early symptom of cardiovascular incident, rather than its cause. Sexual stimulation induces the release of nitrogen oxide (NO) to the penile corpora cavernosa, resulting in the production of cGMP, the essential smooth muscle relaxing factor, resulting in erection. Phosphodiesterase 5 (PDE 5) inhibitors enable degradation of cGMP, which makes them the most commonly used medications in therapy of ED. However, serious adverse effects have been reported, when used along with several medications used in treatment of CVD. Herbal supplements could be used as an alternative of PDE 5 inhibitors in the treatment of ED. This study examines the effect of herbal supplements on oxidative stress (OS) in liver, kidney and testicles of Swiss albino mouse. As biomarkers of OS, superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) were used. The activity of SOD and GSH reduced significantly (p<0,05) for two tested supplements, while MDA levels were significantly increased in the tissues of animals treated with three tested supplements, compared to the control.

• Keywords: dodaci prehrani; erektilna disfunkcija; lipidna peroksidacija; SOD; GSH
• Keywords (english): supplements; erectile dysfunction; lipid peroxidation; SOD; GSH
• Language: croatian
• URN:NBN: urn:nbn:hr:159:844708
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-04 14:07:16