Konjugati ferocen-1,1'-diamina s prirodnim aminokiselinama

master's thesis

• Title (english): The conjugates of ferrocene-1-1'-diamine with natural amino acids
• Author: Tanita Petričević
• Mentor: Lidija Barišić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2015-09-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

U ovom radu opisana je sinteza i konformacijska analiza biokonjugata 1-3 izvedenih iz ferocen-1,1’-diamina i prirodnih aminokiselina (Leu, Phe i Val). Pripravljeni spojevi podvrgnuti su strukturnoj analizi primjenom IR- i -NMR spektroskopije s ciljem utvrđivanja njihovih konformacijskih svojstava. Dobiveni spektroskopski podaci za biokonjugate 1-3 uspoređeni su s eksperimentalnim vrijednostima ranije opisanog alaninskog analoga. Pokazalo se da razgranati bočni ogranci u ispitivanim peptidima donekle ometaju tvorbu unakrsnih vodikovih veza te da se peptidi 1-3 mogu stabilizirati i unutarlančanim vodikovim vezama za razliku od spomenutog alaninskog analoga.

Abstract (english)

This work describes the synthesis and conformational analysis of bioconjugates 1-3 derived from ferrocene-1-1’-diamine and natural amino acids (Leu, Phe, Val). The prepared compounds were subjected to structural analysis by using IR and NMR spectroscopy in order to determine their conformational properties. The obtained spectral data were compared to those of the previously described alanine analogue. It was shown that the branched side chains of the herein described peptides make the formation of the crossed intramolecular hydrogen bonds somewhat difficult. As opposed to their alanine analogue, peptides 1-3 are additionally stabilized through intrachain hydrogen bonds.

• Keywords: ferocen; ferocenski konjugati; peptidi; intramolekulska vodikova veza; konformacijska analiza
• Keywords (english): ferrocene; ferrocene conjugate; peptides; intramolecular hydrogen bond; conformational analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:193275
• Study programme: Title: Molecular Biotechnology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-05 09:41:15