Povezanost dijetetičkih i antropometrijskih parametara s koncentracijom homocisteina, statusom folata i vitamina B12 u žena dobi 65 i više godina

master's thesis

• Title (english): Association of dietetic and anthropometric parameters with levels of homocysteine and folate and vitamin B12 status in women 65 years of age and older
• Author: Matea Ivković
• Mentor: Irena Colić Barić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Nutrition Science); Zagreb
• Defense date and country: 2011-02-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology

Abstract

Povećana razina homocisteina u krvi povezana je s neadekvatnim statusom folata i vitamina B12. Starije osobe su rizična skupina zbog niskog unosa folata i slabe apsorpcije vitamina B12. Cilj rada je bio utvrditi razine homocisteina, folata i vitamina B12 u žena dobi 65 i više godina te povezanost s dijetetičkim i antropometrijskim parametrima. Provedeno je istraživanje sa 61 ženom starijom od 65 godina. Za to predviđenim biokemijskim metodama izmjerene su koncentracije biomarkera, napravljena su ciljana antropometrijska mjerenja te primjenom dijetetiĉkih metodama 24-h prisjećanje i upitnikom o učestalosti konzumiranja hrane i pića(FFQ) su prikupljeni podaci o prehrani. Antropometrijskih parametri (BMI > 25 kg/m2 , WHR > 0,8 i udjel masnog tkiva > 32%) za koje se smatra da su u korelaciji sa povećanom razinom homocisteina imaju gotovo sve ispitanice (80-100%). Prosječni dnevni unos folata je bio manji, a vitamina B12 veći od preporuka (%DRI). Veliki broj ispitanica (86,9%) je imao povišenu razinu homocisteina prema kriteriju >10 μmol/L. Razina homocisteina je negativno korelirala (p<0,05) s razinom folata u serumu, folata u eritrocitima i vitaminom B12 u serumu. S obzirom na poznati rizik od povećane koncentracije Hcy u krvi, preporuča se hranom i/ili dodacima prehrani povećati unos folata.

Abstract (english)

Elevated levels of homocysteine in the blood are associated with inadequate status of folat and vitamin B12. Older people are risk population group due to low folate intake and poor absorption of vitamin B12. The aim of this study was to determine the levels of homocysteine, folate and vitamin B12 in women aged 65 and older, and their connection with the dietary and anthropometric parameters. The research was performed on 61 female over 65 years old. Biochemical methods were used to the determine the concentration of biomarkers, than anthropometric measurements were made and then with dietary methods, 24-h recall and food frequency questionnaire information of food were collected. Anthropometric parameters (BMI> 25 kg/m2 ,WHR> 0,8 and % body fat > 32%) which are believed to be correlated with increased levels of homocysteine have nearly all women (80-100%).Average daily intake of folate was lower and vitamin B12 was higher than the recommendations (% DRI). A large number of patients (86,9%) had elevated homocysteine level according to the reference value of > 10 μmol / L. Homocysteine level was negatively correlated (p <0.05) with the level of serum folate, erythrocyte folate and vitamin B12 in serum. Considering the known risk of increased concentrations of Hcy in the blood, it is recommended to increase folate intake by food or if is needed with supplements.

• Keywords: starija dob; homocistein; folat; vitamin B12; prehrana; biomarkeri
• Keywords (english): older age; homocysteine; folate; vitamin B12; nutrition; biomarkers
• Language: croatian
• URN:NBN: urn:nbn:hr:159:590057
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-30 11:58:04