Priprema i karakterizacija kopulata ferocenoil klorida i timina

undergraduate thesis

• Title (english): Preparation and characterization of derivate fercenoil chlorid and thimine
• Author: Ana Borko
• Mentor: Jasmina Lapić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2015-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology

Abstract

Imajući u vidu da nukleozidni analozi pokazuju značajnu biološku aktivnost, tj. da efikasno djeluju u sprječavanju razmnožavanja malignih stanica čiji je mehanizam djelovanja temeljen na mogućnosti ugradnje u rastući polinukleotidni lanac što uzrokuje prekid daljnje sinteze polinukleotida ili izmjenu funkcije novonastale nukleinske kiseline, u okviru ovog završnog rada višestupanjskom sintezom pripravljen je N1-ferocenoil timin 4. U literaturi je opisan niz ferocenilalkilnih derivata s nukeobazama koji su pokazali jako antitumorsko djelovanje prema karcinomu 755 [1]. Ferocenoilni derivati nukleobaza nisu opisani u literaturi te je sinteza ovog derivata vrlo zanimljiva u svrhu proučavanja kako biološke aktivnosti tako i elektrokemijskih svojstava pripravljenog biokonjugata.

Abstract (english)

Since nucleoside analogues show significant biological activity, ie. they efficienty act in inhibition of reproduction of malignant cells. That mechanism is based on installation capabilities in rising polynucleotide chain which result in inhibition of further synthesis of polynucleotide or exchange in function of newly created nucleic acid. In this final work, N1-ferrocenoil thimine 4 has been prepared by multistage synthesis. In literature it is described a row of ferrocenalkyl-nucleobase derivates which have shown strong antitumor activity against carcinoma 755 [1]. Ferrocenoil-nucleobase derivates were not described in literature so the synthesis of this analogue was interesting in order to study his biological activity and electrochemical properties.

• Keywords: ferocen; nuklobaza; timin; sinteza; spektralna analiza
• Keywords (english): ferrocen; nucleobase; synthesis; spectral analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:030564
• Study programme: Title: Food Technology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-04-25 12:15:10