Perzistentnost ostataka klenbuterola u tjelesnim tekućinama i tkivima svinja nakon subkronične izloženosti anaboličnoj dozi

doctoral thesis

• Title (english): Persistence of clenbuterol residues in body fluids and tissues of pigs exposed to a subchronic anabolic dose
• Author: Jelka Pleadin; MBZ: 273891
• Mentor: Tihomira Gojmerac (mentor); MBZ: 98185
• Committee member: Nada Vahčić (predsjednik povjerenstva); MBZ: 125475
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2006-12-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition
• Universal decimal classification (UDC): 613 - Hygiene. Personal health and hygiene. Dietetics. Occupational diseases. Addictions. Sexual hygiene

Abstract

Utvrđena je raspodjela i eliminacija ostataka klenbuterola u raznom biološkom materijalu svinja kao što je urin, plazma, jetra, bubreg, horioid/ pigmentirani mrežnični epitel i dlaka, koje su bile subkronično izložene djelovanju oralne anaboličke doze klenbuterola, kako bi se procjenila njegova perzistentnost u određenom vremenskom razdoblju. Ustanovljena je izrazita perzistentnost ostataka klenbuterola u pigmentiranom tkivu dlake i horioid/ pigmentiranog mrežničnog epitela u odnosu na jetra i druge uzorke, što ukazuje na prednosti njihove primjene kao novih matriksa u kontroli zlouporabe anabolika klenbuterola, naročito u slučaju kada je prošlo dulje vremensko razdoblje nakon prestanka tretmana.

Abstract (english)

The aim was to determine clenbuterol distribution and residue elimination in biological materials in pigs such as urine, plasma, liver, kidney, choroid/ pigmented retinal epithelium and hair, at subchronic exposure to oral anabolic dose of clenbuterol, in order to assess clenbuterol persistence over a certain period of time. The higher persistence of clenbuterol residues in the pigmented hair tissue and choroid/ pigmented retinal epithelium was determined compared with the liver and other samples. The pig choroid/ pigmented retinal epithelium and hair should be the useful new matrices in the control of clenbuterol abuse as an anabolic, especially at a prolonged time of treatment discontinuation.

• Keywords: Utvrđena je raspodjela i eliminacija ostataka klenbuterola u raznom biološkom materijalu svinja kao što je urin; plazma; jetra; bubreg; horioid/ pigmentirani mrežnični epitel i dlaka; koje su bile subkronično izložene djelovanju oralne anaboličke doze klenbuterola; kako bi se procjenila njegova perzistentnost u određenom vremenskom razdoblju. Ustanovljena je izrazita perzistentnost ostataka klenbuterola u pigmentiranom tkivu dlake i horioid/ pigmentiranog mrežničnog epitela u odnosu na jetra i druge uzorke; što ukazuje na prednosti njihove primjene kao novih matriksa u kontroli zlouporabe anabolika klenbuterola; naročito u slučaju kada je prošlo dulje vremensko razdoblje nakon prestanka tretmana.
• Keywords (english): persistence; clenbuterol; residues; pigs; body fluids; tissues; subchronic; anabolic
• Language: croatian
• URN:NBN: urn:nbn:hr:159:505633
• Promotion: 2009-09-28
• Study programme: Title: Postgraduate PhD Study in Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam (doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-11 11:19:12