Utjecaj fitokemikalija na detoksifikacijski sustav stanica u kulturi

doctoral thesis

• Title (english): Influence of phytochemicals on cellular detoxyfing system of cells in the culture
• Author: Ksenija Durgo; MBZ: 226422
• Mentor: Jasna Franekić Čolić (mentor); MBZ: 85870
• Committee member: Jasna Vorkapić-Furač (predsjednik povjerenstva); MBZ: 53001
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2006-04-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology
• Universal decimal classification (UDC): 60 - Biotechnology. Genetic engineering. Products of cloning

Abstract

U ovom je radu istraženo pet strukturno sličnih flavonoida s obzirom na (i) citotoksični učinak; (ii) promjenu propusnosti stanične membrane; (iii) antioksidativni/prooksidativni učinak; (iv) promjenu bazalne razine ukupnog staničnog glutationa i aktivnosti glutation-S-transferaza; (v) ekspresiju citokroma 1A1; (vi) promjenu ekspresije apoptotičkih proteina. U tu svrhu korištene su stanične linije karcinoma grkljana (HEp2 i CK2), te stanične linije karcinoma grlića maternice (HeLa i HeLa CK).

Abstract (english)

In this thesis, five structurally similar flavonoids were investigated on: (i) cytotoxic effect; (ii) influence on cell membrane permeability; (iii) antioxidant/prooxidant effect in cells; (iv) basal level of total cellular glutathione and glutathione-S-transferases; (v) cytochrome 1A1 expression and (vi) apoptotic proteins expression. Laryngeal carcinoma cell lines (HEp2 and CK2) and cervical carcinoma cell lines were used (HeLa and HeLa CK).

• Keywords: Antioksidans/prooksidans; apoptoza; detoksifikacijski sustavi faze I i II; flavonoidi; stanice karcinoma grkljana; stanice karcinoma grlića maternice
• Keywords (english): antioxidant/prooxidant; apoptosis; detoxyfing systems phase I and II; flavonoids; laryngeal carcinoma cells; cervical carcinoma cells
• Language: croatian
• URN:NBN: urn:nbn:hr:159:043678
• Promotion: 2006-05-31
• Study programme: Title: Postgraduate PhD Study in Biotechnology and Bioprocess Engineering; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-11 11:58:15