Utjecaj razine homocisteina i određenih vitamina B skupine na mineralnu gustoću kosti i biokemijske pokazatelje koštane pregradnje u žena

doctoral thesis

• Title (english): The influence of homocysteine level and specific B vitamins on bone mineral density and biochemical markers of bone turnover in women
• Author: Ivana Rumbak; MBZ: 267962
• Mentor: Irena Colić Barić (mentor); MBZ: 120646
• Committee member: Vladimir Mrša (predsjednik povjerenstva); MBZ: 39525
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2010-12-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology
• Universal decimal classification (UDC): 577 - Biochemistry. Molecular biology. Biophysics

Abstract

U ovom istraživanju cilj je bio utvrditi razinu homocisteina (Hcy) obzirom na poznate rizične čimbenike, te povezanost između razine Hcy, statusa folata, vitamina B12 u krvi i mineralne gustoće kosti (BMD) u ispitanica dobi 45-65 godina (n=174). Od dijetetičkih parametara jedino je konzumacija kave bila povezana s koncentracijom Hcy (p<0,05). Između BMD i razine Hcy te statusa vitamina B12 i folata nije utvrđena korelacija. U ispitanica s blago povećanom razinom Hcy (n=59) koje su bile uključene u randomiziranu kontroliranu dvostruko maskiranu kliničku studiju, nakon 4 mjeseca uzimanja folne kiseline (800 μg/dan) došlo je do povećanja koncentracije folne kiseline i sniženja koncentracije Hcy u usporedbi s kontrolnom skupinom (p<0,05), ali ne i statistički značajne promjene koncentracija biokemijskih pokazatelja koštane pregradnje.

Abstract (english)

The aim of the study was to determine homocysteine (Hcy) level considering known risk factors for elevated Hcy level as well as relationship between Hcy level, folate and vitamin B12 status and bone mineral density (BMD) in women aged 45-65 (n=174). Coffee consumption was the only dietetic parameter associated with Hcy level (p<0,05). Results of this study suggest that Hcy, folate or vitamin B12 levels were not related to BMD. In double blind placebo controlled trial participants with mildly elevated Hcy level (n=59) showed significant increase of folate and vitamin B12 level and significant decrease in Hcy level after 4 months of folic acid supplementation (800 μg/day) compared with placebo group. Biochemical markers of bone turnover levels showed no statistically significant difference after intervention.

• Keywords: biokemijski pokazatelji koštane pregradnje; folat; homocistein; mineralna gustoća kosti; vitamin B12; žene
• Keywords (english): biochemical markers of bone turnover; bone mineral density; folate; homocysteine; vitamin B12; women
• Language: croatian
• URN:NBN: urn:nbn:hr:159:933532
• Promotion: 2011-07-03
• Study programme: Title: Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor znanosti/doktorica znanosti (doktor znanosti/doktorica znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-15 11:04:01