Priprava i biološka aktivnost depsipeptida

undergraduate thesis

• Title (english): Synthesis and biological application of depsipeptides
• Author: Josipa Vlahov
• Mentor: Monika Kovačević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2019-07-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Peptidi čine skupinu spojeva koji se zbog određenih nepovoljnih farmakoloških i biomedicinskih karakteristika, ne mogu koristiti u terapeutske svrhe. Kako bi se poboljšala njihova svojstva u tom smislu, s ciljem kliničke primjene, nastala je skupina spojeva koji se nazivaju peptidomimetici, a oponašaju fizikalna i biokemijska svojstva peptida. Depsipeptidi spadaju u skupinu peptidomimetika, a karakterizira ih zamijena peptidne veze sa esterskom. Osim što se mogu izolirati iz prirodnih organizama kao što su gljive, bakterije i morski organizmi, depsipeptidi se mogu i sintetizirati. Dva načina sinteze koja se najčešće koriste su sinteza u otopini i sinteza na čvrstoj fazi. Depsipeptidi su sve važniji izvor farmakološki aktivnih spojeva koji se koriste za razvoj novih sintetički dobivenih lijekova. Pokuzuju široki sprektar bioloških aktivnosti, a najveći potencijal pokazali su kao antitumorski i antimikrobni agensi.

Abstract (english)

Peptide molecules usually can not be used for therapeutic purposes, due to their unfavourable pharmacological and biomedicinal characteristics. In order to improve their properties, with the intention to provide their therapeutic application, a group of peptidomimetic compounds was created, which mimic the physical and biochemical features of the peptides. Depsipeptides are characterized by the amide-to-ester bond substitution and can be isolated from natural organisms such as fungi, bacteria and marine organisms. Depsipeptides can be synthesized; two methods that are most commonly used are total solution synthesis and solidphase synthesis. Depsipeptides are an increasingly important source of pharmacologically active compounds used to develop new synthetically obtained drugs. They have a wide range of biological activities and have shown the greatest potential as antitumor and antimicrobial agents.

• Keywords: bioaktivni peptidi; depsipeptidi; peptidomimetici; sinteza
• Keywords (english): bioactive peptides; depsipeptides; peptidomimetics; synthesis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:375184
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-07-26 06:20:02