Čalkoni: polifenolni spojevi s raznolikom biološkom aktivnošću

undergraduate thesis

• Title (english): Chalcones: polyphenolic compounds with a diverse biological activity
• Author: Lea Šulc
• Mentor: Veronika Kovač (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2021-07-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Čalkoni su, kao vrsta polifenolnih spojeva, prirodno prisutni u voću, povrću, začinima i čajevima. Posjeduju određene biološke aktivnosti kao što su antitumorska, antimikrobna, antioksidativna i antidijabetička aktivnost, a također mogu djelovati i protuupalno te hepatoprotektivno. Sama se antitumorska aktivnost čalkona povezuje s njihovom sposobnošću djelovanja na pojedine faze karcinogeneze – inicijaciju, promociju i progresiju, a uz to mogu inhibirati stanični ciklus, metastaziranje i angiogenezu te izazvati apoptozu tumorskih stanica. Navedene se biološke aktivnosti čalkona povezuju s brojnim pozitivnim učincima na zdravlje, te se uvelike preporučuje njihovo korištenje u prevenciji određenih bolesti. Budući da su postojeći lijekovi često nedovoljno učinkoviti, znanstvena zajednica nastoji istražiti nove, pri čemu čalkoni služe kao modeli za dizajn i sintezu strukturno sličnih spojeva s poboljšanim farmakološkim karakteristikama, s ciljem unaprjeđenja farmakoterapije raznih bolesti.

Abstract (english)

Chalcones are polyphenolic compounds widely distributed in fruits, vegetables, spices and tea. They possess different biological activities such as antitumor, antimicrobial, antioxidative, antidiabetic, anti-inflammatory and hepatoprotective activity. Chalcones show the ability to modulate different phases of carcinogenesis – initiation, promotion and progression. They can cause cell cycle arrest, inhibit metastasis and angiogenesis and also trigger apoptosis in cancer cells. Different biological activities of chalcones are associated with their positive effects on health. Therefore, they are recommended in prevention of certain diseases. With a view to improving treatment of various diseases, chalcones are used as basic models for the design and synthesis of new structurally related compounds that might have better pharmacological properties.

• Keywords: biološka aktivnost; čalkoni; polifenoli; pretilost
• Keywords (english): biological activity; chalcones; obesity; polyphenols
• Language: croatian
• URN:NBN: urn:nbn:hr:159:307575
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-07-28 12:07:28