Računalna analiza modela metabolizma masti

master's thesis

• Title (english): Computional analysis of fat metabolism model
• Author: Martina Kosić
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2022-04-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

U ovom radu provedena je računalna analiza modela metabolizma masti primjenom programskog paketa CellDesigner i WR Mathematica. Provedene su simulacije modela primjenom različitih početnih koncentracija glukoze i triaciglicerola u krvnoj plazmi pri različitim obrocima (zajutrak, ručak, međuobrok i večera). Metodama lokalne i globalne parametarske osjetljivosti analizirani su najosjetljiviji metaboliti modela. Rezultati simulacija ukazuju na važnost hormona inzulin, ne samo za metabolizam i dostupnost ugljikohidrata u organizmu, nego i za sam metabolizam masti koji se najbolje primjećuje na primjeru dinamike promjene koncentracije neesterificiranih masnih kiselina. Analiza lokalne i globalne parametarske osjetljivosti pokazala je da najveću osjetljivost na promjenu parametara modela ima koncentracija egzogeni triacilglicerola.

Abstract (english)

A computer analysis of the fat metabolism model was performed using the CellDesigner and WR Mathematica software packages. Simulations of the model were performed using different initial blood plasma glucose and triaciglycerol plasma concentration at different meals (breakfast, lunch, snack and dinner). The most sensitive metabolites of the model were analyzed by local and global parametric sensitivity methods. The results of the simulations indicate the importance of the hormone insulin, not only for the metabolism and availability of carbohydrates in the body, but also for the fat metabolism itself, which is best seen in the dynamics of changes in the concentration of non-esterified fatty acids. Analysis of local and global parametric sensitivity showed that the concentration of exogenous triacylglycerol has the greatest sensitivity to changes in model parameters.

• Keywords: metabolizam masti; matematički model; CellDesigner; analiza parametarske osjetljivosti
• Keywords (english): fat metabolism; mathematical model; CellDesigner; parametric sensitivity analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:240808
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-06-29 10:11:30