Uloga tumor supresorskih gena CDH1 I MLH1 u sporadičnim karcinomima dojke

undergraduate thesis

• Title (english): Role of tumor suppressor genes CDH1 AND MLH1 in sporadic breast cancer
• Author: Silvia Ujčić
• Mentor: Reno Hrašćan (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2014-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Rak dojke jedan je od vodećih uzročnika smrti u žena. Rezultat je to uzajamnog djelovanja genetskih i okolišnih čimbenika koji ,karcinom, posljedično svrstavaju u kompleksnu heterogenu bolest. Karcinom se smatra bolešću gena jer se nastanak i progresija tumora razvijaju stupnjevitim promjenama na razini gena što se očituje kao abnormalan i nesvrhovit rast stanica. Skupina gena koja priječi tu zloćudnu preobrazbu na različitim razinama su tumor supresorski geni koji svojim menanizmom popravka imaju spopsobnost vratiti tumorsku stanicu u normalne okvire rasta. Njihov gubitak ili inaktivacija u stanici rezultira razvitkom tumora. U ovom radu pobliže je razjašnjena uloga dvaju tumor supresorskih gena CDH1 i MLH1 ključnih u razvitku sporadičnog karcinoma dojke koji nije pod utjecajem nasljedne obiteljske anamneze.

Abstract (english)

Breast cancer is one of the leading causes of women's death. It's the result of interaction between genetic and environmental factors which consequently classify the cancer as a complex heterogeneous disease. Cancer is considered a disease of genes, because the occurrence and progression of tumor develops by a gradual change on the gene which results as abnormal and unpurposeful cell growth. Group of genes which prevents the malignant transformation at different levels are the tumor suppressor genes which have the ability to restore the tumor cell growth in normal proportions. Their loss or inactivation in the cells, results with tumor evolvement. In this study is further clarified the role of two tumor suppressor genes CDH1 and MLH1 which are key in the evolvement of sporadic breast cancer that is not influenced by familial history.

• Keywords: karcinom dojke; tumor supresorski geni
• Keywords (english): breast cancer; tumor suppressor genes
• Language: croatian
• URN:NBN: urn:nbn:hr:159:156523
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-04-27 10:41:21