Uloga vitamina D i receptora vitamina D u tumorigenezi

undergraduate thesis

• Title (english): Role of vitamin D and vitamin D receptor in tumorigenesis
• Author: Eva Bašić
• Mentor: Lidija Šver (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Laboratory for Biology and Microbial Genetics); Zagreb
• Defense date and country: 2023-07-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Vitamin D je spoj čije se djelovanje na karcinom sve više istražuje. Vitamin D ima sposobnost regulacije ekspresije gena putem svog receptora VDR. Ovaj receptor može vezati biološki aktivni oblik vitamina D, 1,25(OH)₂ D₃. Kada se nalazi u ovom obliku, vitamin D koji se vezao na svoj receptor omogućuje vezanje receptora na DNA molekulu koja se udružuje s transkripcijskim faktorima kako bi se promijenila ekspresija gena koji kodiraju za dijelove mnogih signalnih puteva važnih u procesu tumorigeneze. Zbog toga je cilj ovog rada istražiti i sažeto prikazati koji su to mehanizmi kojima i na koje signalne puteve unutar stanica vitamin D djeluje. Vitamin D djeluje na više signalnih puteva i ostvaruje više učinaka na proces tumorigeneze: antiproliferacijski učinak, stimulira diferencijaciju stanica, inhibira invaziju i metastaziranje stanica karcinoma i inducira apoptozu.

Abstract (english)

Vitamin D is a compound whose effects on cancer are increasingly being studied. Vitamin D regulates gene expression via its receptor VDR. This receptor is only able to bind the biologically active form of vitamin D, 1,25(OH)₂ D₃. In this form, vitamin D bound to the receptor allows the receptor to bind to a DNA molecule and associate with transcription factors to alter the expression of genes that encode parts of many signalling pathways important in tumourigenesis. Therefore, the aim of this work is to investigate and summarise the mechanisms by which vitamin D acts and the signalling pathways in cells that it affects. Vitamin D influences a variety of signalling pathways and has numerous effects on tumourigenesis: antiproliferative effect, inhibition of invasion and metastasis of cancer cells and induction of apoptosis.

• Keywords: vitamin D; receptor vitamina D; tumorigeneza; karcinom; stanica
• Keywords (english): vitamin D; vitamin D receptor; tumorigenesis; cancer; cell
• Language: croatian
• URN:NBN: urn:nbn:hr:159:587404
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-16 10:46:07