Biosintetski potencijal šest novo sekvencioniranih bakterija roda Streptomyces

master's thesis

• Title (english): Biosynthetic potential of six newly sequenced bacteria of the Streptomyces genus
• Author: Andro Vuković
• Mentor: Antonio Starčević (mentor)
• Committee member: Anita Slavica (predsjednik povjerenstva)
• Committee member: Igor Slivac (član povjerenstva)
• Committee member: Jurica Žučko (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Biochemical Engineering); (Section for Bioinformatics); Zagreb
• Defense date and country: 2023-07-24, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Bakterije roda Streptomyces su Gram-pozitivne aerobne bakterije koje tijekom vegetativne faze svog života proizvode mnogobrojne sekundarne metabolite. Oni nisu nužni za rast stanice, ali joj daju određene prednosti nad drugim organizmima u staništu. Mnogi sekundarni metaboliti korisni su za čovječanstvo jer se upotrebljavaju u raznim područjima života. Cilj ovog rada bio je analizirati genome šest bakterija iz roda Streptomyces koje su izolirane iz Jadranskog mora te utvrditi sadrže li one sekundarne metabolite koji pokazuju biotehnološki potencijal. Rezultat AntiSMASH analize pokazao je da ovi genomi sadrže brojne genske nakupine koje sudjeluju u sintezi važnih sekundarnih metabolita te da bi se ove bakterijske vrste mogle koristiti za industrijsku proizvodnju potencijalno korisnih proizvoda.

Abstract (english)

Bacteria of the Streptomyces genus are Gram-positive aerobic bacteria that produce secondary metabolites during the vegetative phase of their life cycle. These metabolites are not necessary for cell growth, but they give the organism certain advantages over other organisms in their habitat. Numerous secondary metabolites are useful for mankind because they are used in various industries. The aim of this work was to analyze the genomes of six bacteria from the Streptomyces genus that were isolated from the Adriatic Sea and to determine whether they contain secondary metabolites that exhibit potential to be utilized in biotechnology. The result of the AntiSMASH analysis showed that these genomes contain gene clusters that participate in the synthesis of important secondary metabolites and that these bacterial species could be used for the industrial production of potentially very important products.

• Keywords: sekundarni metaboliti; anotacija; sastavljanje genoma; usporedna analiza
• Keywords (english): secondary metabolites; annotation; assembly; analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:893740
• Study programme: Title: Molecular Biotechnology; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-14 09:10:12