Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata

master's thesis

• Title (english): Simulation of metabolic insulin signaling pathway model based on menus with different proportions of carbohydrates
• Author: Iva Beneti
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Committee member: Maja Benković (član povjerenstva)
• Committee member: Ivana Rumora Samarin (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2024-03-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Sistemska biologija u nutricionizmu omogućava bolje razumijevanje utjecaja hrane i njezinih komponenti na zdravlje i pojavu bolesti. U ovom radu provedena je simulacija modela signalnog puta metabolizma primjenom jelovnika s različitim udjelom ugljikohidrata (ketogeni, visokougljikohidratni, mediteranski i jelovnik za povremeni post 16:8) u programskom paketu CellDesigner. Rezultati pokazuju da je kod mediteranskog jelovnika zastupljenost ugljikohidrata najveća u zajutraku i večeri dok se kod visokougljikohidratnog jelovnika najveće količine ugljikohidrata nalaze u doručku i ručku, a kod povremenog posta u ručku. Nadalje rezultati simulacija pokazuju nagli porast koncentracije inzulina na početku kao odgovor na povišenje glukoze u krvi. Udio GLUT4 translokacija raste tijekom vremena, obrnuto proporcionalno promjeni koncentracije inzulina. Može se zaključiti da što su veće početne koncentracije inzulina, to je potrebno više vremena da se veže na receptore neovisno o vrsti jelovnika.

Abstract (english)

Systemic biology in nutrition enhances the understanding of food and its components' impact on health and disease occurrence. In this study, a simulation of the metabolic pathway model using dietary plans with different carbohydrate content (ketogenic, high-carbohydrate, Mediterranean, and intermittent fasting 16:8 menu) was performed using the CellDesigner program package. Results indicate that in the Mediterranean menu, carbohydrate prevalence is highest at breakfast and dinner, while in the highcarbohydrate plan, the highest amounts are found at snack and lunch, and in the intermittent fasting plan, at lunch. Simulations showed a rapid insulin concentration increase initially in response to blood glucose elevation. The proportion of GLUT4 translocation increases over time, inversely proportional to changes in insulin concentration. It can be concluded that higher initial insulin concentrations require more time for their binding to receptors, regardless of the type of dietary plan.

• Keywords: metabolizam inzulina; signalni put; matematički model; CellDesigner; sistemska biologija u nutricionizmu
• Keywords (english): insulin metabolism; signalling pathway; mathematical model; CellDesigner; systems biology in nutrition
• Language: croatian
• URN:NBN: urn:nbn:hr:159:175453
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-25 10:04:26