Utjecaj unosa kiseloga kupusa na sastav crijevne mikrobiote aktivnih športaša

doctoral thesis

• Title (english): Impact of sauerkraut intake on the gut microbiota composition of active athletes
• Author: Andrija Karačić
• Mentor: Antonio Starčević (mentor)
• Committee member: Blaženka Kos (predsjednik povjerenstva)
• Committee member: Jurica Žučko (član povjerenstva)
• Committee member: Donatella Verbanac (član povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2025, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology
• Universal decimal classification (UDC): 633/635 - Horticulture. Fruit growing. Viticulture. Gardening

Abstract

Crijevna mikrobiota je od velike važnosti za sportsku izvedbu i zdravlje športaša. Fermentirane namirnice pokazale su se iznimno učinkovitim u personalizaciji crijevne mikrobiote. Cilj ove disertacije bio je ispitati učinak kiseloga kupusa na sastav i funkcionalnost crijevne mikrobiote aktivnih športaša kako bi se ispitao potencijal njegove primjene u personalizaciji njihove crijevne mikrobiote. Nadalje, ispitana je mikrobna zajednica kiseloga kupusa te su praćeni i laboratorijski parametri i rad probave u sklopu intervencije. Provedena su sveukupno tri istraživanja na aktivnim športašima: studija dokazivanja koncepta na profesionalnim športašima, potvrdna studija na rekreativnim športašima te jedna longitudinalna studija na jednom ispitaniku. Pokazali smo kako kod profesionalnih športaša uslijed 10 dana unosa 250g kiseloga kupusa može doći do značajnih promjena u sastavu i funkcionalnosti crijevne mikrobiote, ali ne i po pitanju α-raznolikosti. Kod rekreativnih športaša nakon 10 dana unosa 250g kiseloga kupusa nisu dokazani isti kratkoročni učinci. Time smo pokazali smo kako promjene izazvane intervencijom ovise o početnom sastavu crijevne mikrobiote. Pokazali smo kako unos 250g kiseloga kupusa tokom 10 dana može dugoročno promijeniti sastav i funkcionalnost crijevne mikrobiote. Longitudinalnom studijom te praćenjem probave i nuspojava pokazali smo kako je 250g kiseloga kupusa potrebno unositi minimalno tjedan dana. Utvrđeno je kako 10 dana unosa 250g kiseloga kupusa rezultira značajnim promjenama u diferencijalnoj krvnoj slici i smanjenjem koncentracije vitamina B12. Zaključno možemo ustvrditi kako kiseli kupus ima potencijal u personalizaciji crijevne mikrobiote športaša.

Abstract (english)

The gut microbiota plays a crucial role in athletic performance and the health of athletes. Fermented foods have proven to be effective in personalizing the gut microbiota. This dissertation aimed to investigate the effect of sauerkraut intake on the composition and functionality of the gut microbiota in active athletes to assess its potential application in personalizing their gut microbiota. Additionally, the microbial community of sauerkraut was examined, and laboratory parameters and digestive function were monitored during the intervention. Three studies were conducted on active athletes: a proof-of-concept study on professional athletes, a follow-up study on recreational athletes, and a longitudinal study on a single participant. We demonstrated that a 10-day intake of 250g of sauerkraut can lead to significant changes in the composition and functionality of the gut microbiota in professional athletes, though not in terms of α-diversity. In recreational athletes the same short-term effects were not not observed. We found that the changes induced by the intervention depend on the initial composition of the gut microbiota. We have found that a 10-day intake of 250g of sauerkraut can induce significant long-term changes in the composition and functionality of the gut microbiota Through the longitudinal study and monitoring of digestion and side effects, we determined that a minimum of one week of 250g daily sauerkraut intake is necessary. It was established that a 10-day intake of 250g of sauerkraut results in significant changes in differential blood counts and a decrease in vitamin B12 concentration. In conclusion, sauerkraut has the potential to personalize the gut microbiota of athletes.

• Keywords: crijevna mikrobiota; športaši; profesionalni športaši; fermentirana hrana; kiseli kupus; sinbiotici
• Keywords (english): gut microbiota; athletes; professional athletes; fermented food; sauerkraut; synbiotics
• Language: croatian
• URN:NBN: urn:nbn:hr:159:661068
• Promotion: 2025
• Study programme: Title: Postgraduate PhD Study in Nutrition; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/ doktorica znanosti, područje biotehničkih znanosti, odgovarajuće polje (određeno matičnom strukom) (doktor/ doktorica znanosti, područje biotehničkih znanosti, odgovarajuće polje (određeno matičnom strukom))
• Type of resource: Text
• Extent: 197 str. ; 30 cm
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-03-11 14:01:42