Inhibitori HMG-CoA reduktaze (statini) u prevenciji povišenog kolesterola

undergraduate thesis

• Title (english): Inhibitors of HMG-CoA reductase (statins) in the prevention of high cholesterol
• Author: Ana Buterin
• Mentor: Irena Landeka Jurčević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Food Quality Control); (Laboratory for Food Chemistry and Biochemistry); Zagreb
• Defense date and country: 2011-09-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Pravilna se prehrana već odavno povezuje smanjenjem rizika od kardiovaskularnih bolesti izazvanih aterosklerozom. Tijekom posljednjih se desetljeća povećalo zanimanje za takve učinke hrane i u literaturi se danas može naći niz podataka o sastojcima različitih namirnica i pića, kao i epidemiološki podaci o njihovim mogućim učincima. Iako je općeprihvačena opravdanost davanja inhibitora HMG-CoA reduktaze (statina) radi smanjenja ukupnog i LDL-kolesterola u serumu bolesnika s koronarnom bolešču srca (KBS) i onih koji zbog hiperlipidemije imaju povečani rizik, donedavno nije bilo tako jasno treba li statine davati i osobama s manje izraženim rizikom. Rezultati novijih velikih kliničkih ispitivanja i gotovo dva desetlječa kliničkih iskustava sa statinima pokazuju da su oni vrlo djelotvorni u smanjenju rizika za KBS i u primarnoj i u sekundarnoj prevenciji. Iako su se pristupi istraživanjima mijenjali tijekom godina, cilj im je uvijek bio isti – pronaći one najpogodnije te one doze u kojima bi njihova djelotvornost bila najučinkovitija, a rizik od mogućih posljedica najmanji.

Abstract (english)

Healthy nutrition has been long associated with a lower risk of cardiovascular diseases (CVD) due to atherosclerosis, and particularly coronary heart disease and myocardial infarction. Over the last decades the interest for these effects of food has increased, and the literature today provides a series of data about ingredients of various foodstuffs and beverages, as well as epidemiological data on their possible effects. Although treatment with HMG-CoA reductase inhibitors (statins) to reduce total and LDL cholesterol is clearly indicated in patients with coronary heart disease (CHD) and those with increased risk due to hyperlipidemia, the requirements of patients with lower risk were until recently less straightforward. The results of recent large clinical trials with statins and almost two decades of clinical experience have shown that statins are effective and well tolerated in reducing CHD risk for both primary and secondary prevention. Even though the research approaches have changed through the years, the aim has always been the same; to find the most adequate and most effective dosage with the lowest side effect risk.

• Keywords: statini; HGM-CoA reduktaza; kolesterol; lipoproteini
• Keywords (english): statins; HMG-CoA reductase; cholesterol; lipopoprotein
• Language: croatian
• URN:NBN: urn:nbn:hr:159:412003
• Study programme: Title: Nutrition; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-05-18 09:57:37