Numeričke aproksimacije modela enzimske oksidacije L-dopa u mikroreaktoru

master's thesis

• Title (english): Numerical approximations of a model of enzymatic oxidation of L-dopa in microreactor
• Author: Ana Ptičar
• Mentor: Želimir Kurtanjek (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2010-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Mikroreaktori su se pokazali učinkovitijima od makroskopskih sustava u mnogim dosadašnjim istraživanjima u području kemijskih i biokemijskih procesa. Neke od najbitnijih karakteristika mikroreaktora su veliki omjer dodirne površine u odnosu na volumen uređaja, učinkovit prijenos mase i topline te jednostavna kontrola procesnih uvjeta. U ovome radu pokušalo se ispitati mogućnosti jednostavnih numeričkih aproksimacija za rješavanje sustava parcijalnih diferencijalnih jednadžbi koje opisuju procese biokonverzija u mikroreaktoru na primjeru enzimske oksidacije 3,4-dihidroksifenil-L-alanina (L-DOPA) lakazom u mikroreaktoru sa dva ulaza i dva izlaza. Na temelju matematičkih modela izvedenih u okviru ovoga rada može se zaključiti da se jednostavne aproksimacije mogu upotrijebiti za rješavanje parcijalnih diferencijalnih jednadžbi koje opisuju proces oksidacije L-DOPA katalizirane enzimom lakazom u mikroreaktorskom sustavu sa dva ulaza i dva izlaza za visoke protoke te niske ulazne koncentracije supstrata.

Abstract (english)

Microreactors are more effective compared to macroscopic systems in many studies in field of chemical and biochemical processes. Some of the most important characteristics of microreactors are large surface area to volume ratio, effective mass and heat transfer and easy control of process conditions. This study attempted to examine the possibility of simple numerical approximations for solving systems of partial differential equations that describe the process of bioconversions in microreactors. The example of enzymatic oxidation of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) catalyzed by laccase in microreactor with two inputs and two outputs was analyzed. Based on mathematical models derived in this study it can be concluded that the simple approximations can be used for solving partial differential equations that describe the process of oxidation of L-DOPA in microreactor system with two inputs and two outputs for high flow rates and low input substrate concentrations.

• Keywords: L-DOPA; matematičko modeliranje; mikroreaktor
• Keywords (english): L-DOPA; mathematical modeling; microreactor
• Language: croatian
• URN:NBN: urn:nbn:hr:159:850275
• Study programme: Title: Biotechnology; specializations in: Biochemical Engineering; Course: Biochemical Engineering; Study programme type: university; Study level: graduate; Academic / professional title: diplomirani inženjer biotehnologije; smjer biokemijsko inženjerstvo (diplomirani inženjer biotehnologije; smjer biokemijsko inženjerstvo)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2017-08-29 07:26:28