Utjecaj deprotonirajućeg agensa na tijek reakcije kopulacije ferocena na adenin

undergraduate thesis

• Title (english): Influence of deprotonating agent on the course of coupling reaction of ferrocene with adenine
• Author: Karlo Svrze
• Mentor: Senka Djaković (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2016-06-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology

Abstract

Analozi nukleozida, među kojima i kopulati nukleobaza s ferocenskim derivatom, pokazuju značajno biološko djelovanje te su stoga važno područje istraživanja. Uz svoje biološko djelovanje, analozi također pokazuju i zanimljiva elektrokemijska svojstva. Cilj ovog završnog rada je ispitati reaktivnost NaH kao deprotonirajućeg agensa na regioselektivnost reakcija priprave kopulata ferocenskog derivata i nukleobaze adenina s karbonilnom podjedinicom kao poveznicom. Posebna pozornost posvećena je vremenu deproktecije, kao jednom od faktora koji može utjecati na usmjerenje reakcije prema nastajanju N9-ferocenoil-adenina. Struktura pripravljenih spojeva potvrđene je IR i NMR spektroskopijom.

Abstract (english)

Ferrocene modified nucleobases are nucleoside analogues that represent an important scientific research field. They possess significant biological activity and electrochemical potential. The main goal of this final work was to test reactivity of deprotonating agent NaH on the regioselectivity of chemical reaction considering the time of deprotection as one of the factors that direct reaction towards N9-ferocenoyl formation. Chemical reaction includes preparation of adenine derivate of ferrocene linked with carbonyl subunit. Structure of prepared compounds was confirmed using IR- and NMR- spectroscopy

• Keywords: ferocen; adenin; kopulati; spektralna analiza
• Keywords (english): ferrocene; adenine; couples; spectral analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:159:931838
• Study programme: Title: Food Technology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-04-24 12:03:29