Primjena biokatalize u farmaceutskoj i industriji finih kemikalija

undergraduate thesis

• Title (english): Application of biocatalysts in the pharmaceutical and fine chemicals industry
• Author: Anamarija Pavić
• Mentor: Mojca Čakić Semenčić (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Physical Chemistry and Corrosion); Zagreb
• Defense date and country: 2017-09-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology

Abstract

Cilj ovog rada bio je predstaviti neke od suvremenih metoda priprave farmaceutskih i proizvoda industrije finih kemikalija koje ne narušavaju ekološku i ekonomsku ravnotežu već se baziraju na principima zelene kemije. Poseban naglasak stavljen je na biokatalizu, odnosno transformaciju tvari, kemijskog ili biološkog podrijetla, primjenom enzima ili cijelih stanica dobivenih iz živih organizama. Različite vrste biokatalizatora učinkovito kataliziraju sintezu različitih kemijskih proizvoda, a njihova visoka selektivnost pritom doprinosi uštedi sirovina, energije i vremena. U radu su opisane prednosti biokatalize u usporedbi s konvencionalnom kemijskom sintezom. Također, dan je pregled nekoliko biokatalitičkih proizvodnih postupaka, poput proizvodnje L-karnitina, hijaluronske i kafeinske kiseline, koji su zamijenili klasičnu kemijsku sintezu.

Abstract (english)

The aim of this thesis was to present some of the modern methods of preparation of pharmaceuticals and fine chemicals, that do not disturb the ecological and economic balance, but are based on the principles of green chemistry. Particular emphasis is placed on biocatalysis, i.e. transformation of chemical or biological compounds, using enzymes or whole cells obtained from living organisms. Different types of biocatalysts effectively catalyze the synthesis of various chemical products, and their high selectivity contributes to significant resources as well as energy and time consumption savings. The thesis describes the advantages of biocatalysis compared with conventional chemical synthesis. Also, several biocatalytic processes, such as L-carnitine, hyaluronic and caffeic acid production, which replaced the classical chemical synthesis are described.

• Keywords: biokataliza; ekološka održivost; fine kemikalije; zeleni procesi
• Keywords (english): biocatalysis; ecological sustainability; fine chemicals; green processes
• Language: croatian
• URN:NBN: urn:nbn:hr:159:508110
• Study programme: Title: Biotechnology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-09-12 09:21:23