Ciljana atenuacija virusa mumpsa na temelju virusnih faktora koji moduliraju mehanizme urođene imunosti

doctoral thesis

• Title (english): Targeted attenuation of mumps virus by viral factors that modulate the innate immune response
• Author: Maja Jagušić
• Mentor: Maja Šantak (mentor)
• Committee member: Višnja Gaurina-Srček (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; Zagreb
• Defense date and country: 2017-11-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Biotechnology
• Universal decimal classification (UDC): 612 - Physiology

Abstract

Cilj ovog istraživanja bio je karakterizirati indukciju mehanizama urođene imunosti na viruse mumpsa različitog stupnja atenuacije. Kao virusni faktori koji mogu modulirati te mehanizme ispitane su defektne intereferirajuće čestice prisutne u virusnoj suspenziji te ekspresija virusnog proteina V. Proizašla saznanja primijenjena su za ciljanu atenuaciju divljeg soja virusa mumpsa kao modela za razvoj novog atenuiranog cjepiva.

Abstract (english)

The aim of this study was to characterize the innate immune responses to mumps viruses of different attenuation level. Defective interfering particles present in the viral suspensions and expression of the viral V protein were examined as viral factors critical for modulation of these responses. The gained knowledge was further applied for targeted attenuation of a wild-type mumps virus as a model for development of a new attenuated vaccine.

• Keywords: mumps; živa atenuirana cjepiva; interferon; atenuacija; defektne interferirajuće čestice; protein V
• Keywords (english): mumps; live-attenuated vaccine; interferon; attenuation; defective interfering particles; V protein
• Language: croatian
• URN:NBN: urn:nbn:hr:159:936217
• Study programme: Title: Postgraduate PhD Study in Biotechnology and Bioprocess Engineering; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2018-05-18 11:22:31