Primjena NMR spektroskopije u metabolomici

undergraduate thesis

• Title (english): Application of nm spectroscopy in metabolomics
• Author: Martina Mihaljević
• Mentor: Monika Kovačević (mentor)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Chemistry and Biochemistry); (Laboratory for Organic Chemistry); Zagreb
• Defense date and country: 2019-07-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Food Technology

Abstract

Metabolomika je jedno od novih područja istraživanja koje omogućuje bolje ra umijevanje bioloških sustava. Najčešća instrumentalna metoda koja se koristi u ovom području je nuklearna magnetska re oancija (NMR). Metabolomske metode zasnovane na NMR pružaju informaciju o koncentraciji metabolita koja se mijenja pod utjecajem raznih čimbenika. Jedan od čimbenika je bolest, stoga je pomoću metabolomskih metoda moguće utvrditi mnoge biomarkere bolesti. I toga ra loga predstavljaju potencijalno vrlo važan dijagnostički alat. Otkrivanje biomarkera je ključno i a shvaćanje patologije bolesti, te praćenje učinkovitosti liječenja. Zbog prisutnih nedostataka (slaba osjetljivost, veličina uređaja, otkriće biomarkera a mnoge bolesti je još uvijek veliki i a ov...) primjena u kliničkoj medicni nije još moguća. Potreban je daljnji razvoj ovih metoda, a neke od potencijalnih primjena su prikazane u ovome radu.

Abstract (english)

Metabolomics is one of the new research fields that gives a better understanding of biological system. The most common instrumental tool used in this research is Nuclear Magnetic Resonance (NMR). NMR-based metabolomics provides information on the concentration of a metabolite under the influence of various factors. One of the factors is a disease, so metabolomics methods can be used to identify many biomarkers of the disease. Because of this, these methods are potentially very important diagnostic tools. Biomarker detection is also crucial for understanding pathology of disease and monitoring the effect of treatment interventions. Due to the present deficiencies (weak sensitivity, device size, the discovery of biomarkers for many diseases is still a big challenge...) application in clinic medicine is not possible yet. Further development of these methods is required, as well as some of the potential application is presented in this paper.

• Keywords: bolest; instrumentalna analiza; metabolomika; nuklearna magnetska rezonanca
• Keywords (english): disease; instrumental analysis; metabolomic; nuclear magnetic resonance
• Language: croatian
• URN:NBN: urn:nbn:hr:159:383975
• Study programme: Title: Food Technology; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-07-16 09:56:58