Modeliranje utjecaja različitih koncentracija glutena na aktivaciju imunoodgovora kod celijakije

master's thesis

• Title (english): Modelling the influence of different gluten concentrations on immunoresponse activation in celiac disease
• Author: Sandra Remenar
• Mentor: Ana Jurinjak Tušek (mentor)
• Committee member: Jasenka Gajdoš Kljusurić (predsjednik povjerenstva)
• Granter: University of Zagreb; Faculty of Food Technology and Biotechnology; (Department of Process Engineering); (Laboratory for Measurement, Regulation and Automatisation); Zagreb
• Defense date and country: 2020-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Nutrition

Abstract

Celijakija je postala ozbiljan javnozdravstveni problem koji sa sobom nosi brojne popratne bolesti. Prehrana bez glutena trenutno je jedini lijek u borbi protiv te bolesti. U ovome radu proveden je dizajn i simulacije modela imunološkog odgovora kod celijakije u programskom paketu CellDesigner. Ispitan je utjecaj različitih početnih koncentracija glutena nakon čega se pratila koncentracija metabolita, odnosno jačina imunoodgovora. Početne koncentracije određene su na temelju osmišljenih jelovnika za opću populaciju i za osobe oboljele od celijakije. Određeni su ključni kinetički parametri modela analizom globalne i lokalne osjetljivosti. Matematičko modeliranje pokazalo se vrlo korisnim u razumijevanju složenih metaboličkih procesa unutar stanica.

Abstract (english)

Celiac disease has become a serious public health problem that carries with it a number of comorbidities. A gluten-free diet is currently the only cure for this disease. In this paper, the design and simulations of the immune response model in celiac disease in the CellDesigner software package were performed. The influence of different initial gluten concentrations was examined, after which the concentration of metabolites, and the strength of the immune response was monitored. Initial concentrations were determined on the basis of designed menus for the general population and for people with celiac disease. Key kinetic parameters of the model were determined by global and local sensitivity analysis. Mathematical modelling has proven to be very useful in understanding complex metabolic processes within cells.

• Keywords: celijakija; CellDesigner; imunoodgovor; modeliranje
• Keywords (english): Celiac disease; CellDesigner; immune response; moulding
• Language: croatian
• URN:NBN: urn:nbn:hr:159:544502
• Study programme: Title: Nutrition; Study programme type: university; Study level: graduate; Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-07-20 12:04:55